Biology:FMR1-AS1 gene
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Short description: Non-coding RNA in the species Homo sapiens
 Generic protein structure example |
In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene.[1] Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fragile X syndrome.[1][2] FMR1-AS1 has an anti-apoptotic function.[2]
See also
- Long noncoding RNA
References
- ↑ Jump up to: 1.0 1.1 "An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.". Hum Mol Genet 16 (24): 3174–3187. 2007. doi:10.1093/hmg/ddm293. PMID 17921506.
- ↑ Jump up to: 2.0 2.1 "A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome.". PLOS ONE 3 (1): e1486. 2008. doi:10.1371/journal.pone.0001486. PMID 18213394. Bibcode: 2008PLoSO...3.1486K.
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