Biology:FMR1-AS1 gene

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Short description: Non-coding RNA in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene.[1] Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fragile X syndrome.[1][2] FMR1-AS1 has an anti-apoptotic function.[2]

See also

  • Long noncoding RNA

References

  1. Jump up to: 1.0 1.1 "An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.". Hum Mol Genet 16 (24): 3174–3187. 2007. doi:10.1093/hmg/ddm293. PMID 17921506. 
  2. Jump up to: 2.0 2.1 "A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome.". PLOS ONE 3 (1): e1486. 2008. doi:10.1371/journal.pone.0001486. PMID 18213394. Bibcode2008PLoSO...3.1486K.  open access