Biology:FOXO6
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.[1]
FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.[2] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.[2] In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.[2]
References
- ↑ "Entrez Gene: Forkhead box O6". https://www.ncbi.nlm.nih.gov/gene/100132074.
- ↑ 2.0 2.1 2.2 "FoxO integration of insulin signaling with glucose and lipid metabolism". Journal of Endocrinology 233 (2): R67–R79. 2017. doi:10.1530/JOE-17-0002. PMID 28213398.
Further reading
- "FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics". The Journal of Biological Chemistry 278 (38): 35959–67. September 2003. doi:10.1074/jbc.M302804200. PMID 12857750.
- "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine 16 (7–8): 247–53. 2010. doi:10.2119/molmed.2009.00159. PMID 20379614.
- "Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans". Aging Cell 10 (4): 622–8. August 2011. doi:10.1111/j.1474-9726.2011.00698.x. PMID 21388494.
- "FoxO transcription factors; Regulation by AKT and 14-3-3 proteins". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813 (11): 1938–45. November 2011. doi:10.1016/j.bbamcr.2011.06.002. PMID 21708191.
- "FoxO6 integrates insulin signaling with gluconeogenesis in the liver". Diabetes 60 (11): 2763–74. November 2011. doi:10.2337/db11-0548. PMID 21940782.
- "FoxO6 in glucose metabolism (FoxO6)". Journal of Diabetes 5 (3): 233–40. September 2013. doi:10.1111/1753-0407.12027. PMID 23324123.
- "FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc". FEBS Letters 587 (14): 2105–11. July 2013. doi:10.1016/j.febslet.2013.05.027. PMID 23714368.
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