Biology:FRAT1
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Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.[1][2]
The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.[2]
References
- ↑ "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas". EMBO J 16 (3): 441–50. Mar 1997. doi:10.1093/emboj/16.3.441. PMID 9034327.
- ↑ 2.0 2.1 "Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10023.
Further reading
- "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.". EMBO J. 18 (15): 4233–40. 1999. doi:10.1093/emboj/18.15.4233. PMID 10428961.
- "FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer.". Int. J. Oncol. 19 (2): 311–5. 2001. doi:10.3892/ijo.19.2.311. PMID 11445844.
- "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.". Structure 9 (12): 1143–52. 2002. doi:10.1016/S0969-2126(01)00679-7. PMID 11738041.
- "Molecular cloning and expression of proto-oncogene FRAT1 in human cancer.". Int. J. Oncol. 20 (4): 785–9. 2002. doi:10.3892/ijo.20.4.785. PMID 11894125.
- "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.". Gene 291 (1–2): 17–27. 2002. doi:10.1016/S0378-1119(02)00594-2. PMID 12095675.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.". J. Biol. Chem. 278 (16): 14066–73. 2003. doi:10.1074/jbc.M213265200. PMID 12556519.
- "Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay.". Genome Res. 13 (7): 1765–74. 2003. doi:10.1101/gr.529803. PMID 12805274.
- "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. 2004. doi:10.1038/nature02462. PMID 15164054.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours.". Br. J. Cancer 94 (5): 686–91. 2006. doi:10.1038/sj.bjc.6602988. PMID 16479254.
- "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A.". J. Biol. Chem. 281 (46): 35021–9. 2007. doi:10.1074/jbc.M607003200. PMID 16982607.
External links
- FRAT1 human gene location in the UCSC Genome Browser.
- FRAT1 human gene details in the UCSC Genome Browser.
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