Biology:FSAF1
 Generic protein structure example |
40S small subunit processome assembly factor 1 is a protein that in humans is encoded by the gene FSAF1.[1] The FSAF1 protein participates in assembling ribosomes (ribosome biogenesis) in the nucleolus.[1] In particular, it is part of the ribosome small subunit (SSU) processome, which is the earliest precursor to the SSU.[1]
Gene
In humans FSAF1 is located on the minus strand of chromosome 1 and on the cytogenetic band 1q42.2 along with 193 other genes.[2] Notably, the gene upstream of FSAF1 is GNPAT, and the gene downstream of FSAF1 is TRIM67. When this gene is transcribed in humans, FSAF1 most often forms an mRNA of 1458 base pairs long which is composed of seven exons. There are at least nine others alternative splice forms in humans that produce proteins. They range in size from 129 base pairs (2 exons) to 1458 base pairs (7 exons).[3]
Protein
The human protein has been shown to be both phosphorylated and acetylated.[4][5][6][7][8][9]
References
- ↑ 1.0 1.1 1.2 "Q8NDD1 · FSAF1_HUMAN". UniProt consortium. https://www.uniprot.org/uniprotkb/Q8NDD1/entry.
- ↑ "Browse Homo sapiens ORF cDNA clones by chromosome 1, map 1q42, page 1". http://www.genscript.com/cgi-bin/orf/browse.pl?species=9606&type=locus&chromosome=1&locus=1q42.
- ↑ "AceView: Gene:C1orf131, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=c1orf131&submit=Go.
- ↑ "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.". Science Signaling 3 (104): ra3. January 2010. doi:10.1126/scisignal.2000475. PMID 20068231.
- ↑ "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.". Analytical Chemistry 80 (24): 9526–9533. December 2008. doi:10.1126/scisignal.2000475. PMID 20068231. http://pubs.acs.org/doi/abs/10.1021/ac801708p. Retrieved April 26, 2015.
- ↑ "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.". Science 316 (5828): 1160–1166. May 2007. doi:10.1126/science.1140321. PMID 17525332. Bibcode: 2007Sci...316.1160M.
- ↑ "Identification of novel phosphorylation modification sites in human proteins that originated after the human–chimpanzee divergence". Bioinformatics 27 (18): 2494–501. July 9, 2011. doi:10.1093/bioinformatics/btr426. PMID 21775310.
- ↑ "A quantitative atlas of mitotic phosphorylation.". Proceedings of the National Academy of Sciences of the United States of America 105 (31): 10762–10767. August 2008. doi:10.1073/pnas.0805139105. PMID 18669648. Bibcode: 2008PNAS..10510762D.
- ↑ "Lysine acetylation targets protein complexes and co-regulates major cellular functions.". Science 325 (5942): 834–40. August 2010. doi:10.1126/science.1175371. PMID 19608861. Bibcode: 2009Sci...325..834C.
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