Biology:Fast endophilin-mediated endocytosis
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Short description: Endocytic pathway found in eukaryotic cells
Fast endophilin-mediated endocytosis (FEME) is an endocytic pathway found in eukaryotic cells. It requires the activity of endophilins as well as dynamins, but does not require clathrin.[1]
In Clathrin-dependent endocytic pathways, endosomes budding from the cell membrane into the cell will form in clathrin pits, and be coated by clathrin triskelions. In FEME however, endosomes form when coated by actin, and internalise endophilin A2.
Function
Each endocytic pathway focuses on a particular component, and FEME is primarily involved in transporting receptors. These include receptors for acetylcholine and IL-2.[2]
Associated proteins
References
- ↑ "Molecular mechanism of Fast Endophilin-Mediated Endocytosis". The Biochemical Journal 477 (12): 2327–2345. June 2020. doi:10.1042/bcj20190342. PMID 32589750.
- ↑ "Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics". Nature Nanotechnology 16 (3): 266–276. March 2021. doi:10.1038/s41565-021-00858-8. PMID 33712737. Bibcode: 2021NatNa..16..266R.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Boucrot, Emmanuel; Ferreira, Antonio P. A.; Almeida-Souza, Leonardo; Debard, Sylvain; Vallis, Yvonne; Howard, Gillian; Bertot, Laetitia; Sauvonnet, Nathalie et al. (January 2015). "Endophilin marks and controls a clathrin-independent endocytic pathway" (in en). Nature 517 (7535): 460–465. doi:10.1038/nature14067. ISSN 0028-0836. PMID 25517094. Bibcode: 2015Natur.517..460B. http://www.nature.com/articles/nature14067.
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