Biology:Fibrin monomer
Fibrin monomers are monomers of fibrin which are formed by the cleavage of fibrinogen by thrombin.[1] Levels of fibrin monomers can be measured using blood tests and can serve as a marker of in vivo fibrinogenesis and coagulation activation.[1][2][3] They may be useful in the evaluation of hypercoagulability,[1] as reflected in research studies done using fibrin monomers.
Levels of fibrin monomers may be increased with pregnancy[1] and by estrogen-containing combined birth control pills.[2]
Research
Significance in venous thromboembolism
Increased amount of soluble fibrin monomers in the blood along with serum D-dimers have been found to be indicators of venous thromboembolism (VTE).[4][5] Detection of VTE in such a way have implications for treating VTE taking place during pregnancy and after hepatobiliary-pancreatic surgery.[4][5]
References
- ↑ 1.0 1.1 1.2 1.3 "The Clinical Significance of Fibrin Monomers". Thromb Haemost 118 (11): 1856–1866. November 2018. doi:10.1055/s-0038-1673684. PMID 30312978.
- ↑ 2.0 2.1 "Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk". Semin Thromb Hemost 46 (8): 872–886. November 2020. doi:10.1055/s-0040-1714140. PMID 33080636.
- ↑ "Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. effects on hemostasis". Expert Rev Clin Pharmacol 10 (10): 1129–1144. October 2017. doi:10.1080/17512433.2017.1356718. PMID 28712325.
- ↑ 4.0 4.1 Grossman, Karin B.; Arya, Roopen; Peixoto, Alberto B.; Akolekar, Ranjit; Staboulidou, Ismini; Nicolaides, Kypros H. (October 2016). "Maternal and pregnancy characteristics affect plasma fibrin monomer complexes and D-dimer reference ranges for venous thromboembolism in pregnancy" (in en). American Journal of Obstetrics and Gynecology 215 (4): 466.e1–466.e8. doi:10.1016/j.ajog.2016.05.013. PMID 27179442. https://kclpure.kcl.ac.uk/portal/en/publications/825dde82-ff3d-4ba7-94ab-d681d6fc49a2.
- ↑ 5.0 5.1 Hayashi, Hikaru; Shimizu, Akira; Kubota, Koji; Notake, Tsuyoshi; Sugenoya, Shinsuke; Masuo, Hitoshi; Hosoda, Kiyotaka; Yasukawa, Koya et al. (January 2022). "Asymptomatic Venous Thromboembolism After Hepatobiliary–Pancreatic Surgery: Early Detection Using D-dimer and Soluble Fibrin Monomer Complex Levels" (in en). Annals of Gastroenterological Surgery 6 (1): 109–118. doi:10.1002/ags3.12495. ISSN 2475-0328. PMID 35106421.
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