Biology:Firre (gene)
From HandWiki
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Firre (functional intergenic repeating RNA element) is a long non-coding RNA located on chromosome X. It is retained in the nucleus via interaction with the nuclear matrix factor hnRNPU.[1] It mediates trans-chromosomal interactions[1] and anchors the inactive X chromosome to the nucleolus.[2] It plays a role in pluripotency[3] and adipogenesis.[4]
See also
- Long noncoding RNA
References
- ↑ 1.0 1.1 "Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre". Nature Structural & Molecular Biology 21 (2): 198–206. Feb 2014. doi:10.1038/nsmb.2764. PMID 24463464.
- ↑ "The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation". Genome Biology 16 (52): 52. 2015. doi:10.1186/s13059-015-0618-0. PMID 25887447.
- ↑ "Regulation of the ESC transcriptome by nuclear long noncoding RNAs". Genome Research 25 (9): 1336–1346. Sep 2015. doi:10.1101/gr.189027.114. PMID 26048247.
- ↑ "Long noncoding RNAs regulate adipogenesis". Proceedings of the National Academy of Sciences of the United States of America 110 (9): 3387–3392. Feb 2013. doi:10.1073/pnas.1222643110. PMID 23401553.
Further reading
- "RNA Function. RNA and dynamic nuclear organization". Science 345 (6202): 1240–1241. Sep 2014. doi:10.1126/science.1252966. PMID 25214588.
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