Biology:Folate-binding protein
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Short description: Class of proteins
Folate-binding protein (FBP) are proteins that bind folate, typically the folate receptors and reduced folate carrier.[1]
FBP can be a marker for ovarian cancer.[2]
FBP can be measured to help in tumour classification to aid treatment, as it is over-expressed (20-80 fold) in more than 90% of ovarian and endometrial cancers, as well as 20-50% of breast, lung, colorectal, and renal cell carcinomas. FBP has very limited tissue distribution and expression in non-malignant tissue, making it a good immunotherapy target.[3]
Alternative usage
FBP can refer to protein(s) (e.g. extracted from cow's milk) used to do folic acid assays.[4]
References
- ↑ Kelemen, L. E. (2006). "The role of folate receptor a in cancer development, progression and treatment: Cause, consequence or innocent bystander?". Int. J. Cancer 119 (2): 243–50. doi:10.1002/ijc.21712. PMID 16453285.
- ↑ Trowsdale, John; Foulkes, William D.; Jones, Tania A.; Campbell, Ian G. (1991). "Folate-binding Protein Is a Marker for Ovarian Cancer". Cancer Research 51 (19): 5329–5338. PMID 1717147. http://cancerres.aacrjournals.org/content/51/19/5329.short.
- ↑ http://www.marketwatch.com/story/galena-biopharma-to-present-at-the-10th-annual-biotechnology-investor-forum-2011-10-21 [|permanent dead link|dead link}}]
- ↑ "Laboratory assessment of folate (vitamin B9) status". Journal of Clinical Pathology 71 (11): 949–956. November 2018. doi:10.1136/jclinpath-2018-205048. PMID 30228213.
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