Biology:G6B
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein G6b is a protein that in humans is encoded by the G6B gene, or C6orf25.[1][2][3]
This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
References
- ↑ "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J Immunol 163 (1): 278–87. Jul 1999. PMID 10384126.
- ↑ "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2". J Biol Chem 276 (45): 42070–6. Nov 2001. doi:10.1074/jbc.M103214200. PMID 11544253.
- ↑ 3.0 3.1 "Entrez Gene: C6orf25 chromosome 6 open reading frame 25". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80739.
Further reading
- "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M.
- "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. 2004. doi:10.1101/gr.1736803. PMID 14656967.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin". FEBS Lett. 579 (11): 2355–8. 2005. doi:10.1016/j.febslet.2005.03.032. PMID 15848171.
- "The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro". Blood 109 (11): 4806–9. 2007. doi:10.1182/blood-2006-09-047449. PMID 17311996.
- "G6b-B cell surface inhibitory receptor expression is highly restricted to CD4+ T-cells and induced by interleukin-4-activated STAT6 pathway". Hum. Immunol. 68 (8): 708–14. 2007. doi:10.1016/j.humimm.2007.04.008. PMID 17678728.
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