Biology:GAL3ST1
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Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.[1][2][3]
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.[3]
References
- ↑ Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence". Genome Res 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- ↑ "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem 272 (8): 4864–8. Apr 1997. doi:10.1074/jbc.272.8.4864. PMID 9030544.
- ↑ 3.0 3.1 "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9514.
Further reading
- Siegrist HP; Jutzi H; Steck AJ et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta 489 (1): 58–63. doi:10.1016/0005-2760(77)90231-4. PMID 911873.
- Stein C; Gieselmann V; Kreysing J et al. (1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252–9. doi:10.1016/S0021-9258(19)85079-2. PMID 2562955.
- "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun. 52 (3): 951–8. 1973. doi:10.1016/0006-291X(73)91029-2. PMID 4710574.
- "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694–702. 1971. doi:10.1016/S0021-9258(18)61991-X. PMID 5562350.
- Costantino-Ceccarini E; Waehneldt TV; Ginalski H et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. 7 (1): 1–12. doi:10.1007/BF00965064. PMID 6280086.
- "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem. 38 (1): 233–41. 1982. doi:10.1111/j.1471-4159.1982.tb10875.x. PMID 6955451.
- Honke K; Yamane M; Ishii A et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". J. Biochem. 119 (3): 421–7. doi:10.1093/oxfordjournals.jbchem.a021258. PMID 8830034.
- Tsuda M; Egashira M; Niikawa N et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". Eur. J. Biochem. 267 (9): 2672–9. doi:10.1046/j.1432-1327.2000.01281.x. PMID 10785389.
- "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". Biochem. J. 368 (Pt 1): 317–24. 2002. doi:10.1042/BJ20020946. PMID 12175333.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Collins JE; Wright CL; Edwards CA et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
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