Biology:GMEB1
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Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene.[1][2][3]
Function
This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.[3]
Interactions
GMEB1 has been shown to interact with TRIM63.[4]
References
- ↑ "Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein". FEBS Lett 452 (3): 170–176. Jul 1999. doi:10.1016/S0014-5793(99)00634-1. PMID 10386584.
- ↑ "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol 19 (11): 7741–50. Nov 1999. doi:10.1128/MCB.19.11.7741. PMID 10523663.
- ↑ 3.0 3.1 "Entrez Gene: GMEB1 glucocorticoid modulatory element binding protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10691.
- ↑ "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J Cell Biol 157 (1): 125–136. 2002. doi:10.1083/jcb.200108089. PMID 11927605.
Further reading
- "Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family". FEBS Lett. 468 (2–3): 203–210. 2000. doi:10.1016/S0014-5793(00)01209-6. PMID 10692587.
- "Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins". Nucleic Acids Res. 28 (8): 1819–1829. 2000. doi:10.1093/nar/28.8.1819. PMID 10734202.
- "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins". Mol. Endocrinol. 14 (7): 1010–1027. 2000. doi:10.1210/me.14.7.1010. PMID 10894151.
- "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J. Mol. Biol. 314 (5): 1029–1039. 2002. doi:10.1006/jmbi.2000.5198. PMID 11743720.
- "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors". J. Biol. Chem. 277 (15): 12541–12549. 2002. doi:10.1074/jbc.M112330200. PMID 11812797.
- "Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions". Mol. Endocrinol. 17 (7): 1283–1295. 2004. doi:10.1210/me.2002-0409. PMID 12702733.
- "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain". Biochem. Biophys. Res. Commun. 325 (4): 1246–1251. 2005. doi:10.1016/j.bbrc.2004.10.145. PMID 15555560.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury". J. Biol. Chem. 281 (16): 11397–11404. 2006. doi:10.1074/jbc.M510597200. PMID 16497673.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. 2006. doi:10.1038/nbt1240. PMID 16964243.
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