Biology:GMEB2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glucocorticoid modulatory element-binding protein 2 is a protein that in humans is encoded by the GMEB2 gene.[1][2][3]
This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.[3]
References
- ↑ "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol 19 (11): 7741–50. Nov 1999. doi:10.1128/MCB.19.11.7741. PMID 10523663.
- ↑ "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J Mol Biol 314 (5): 1029–39. Dec 2001. doi:10.1006/jmbi.2000.5198. PMID 11743720.
- ↑ 3.0 3.1 "Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26205.
Further reading
- "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. 2000. doi:10.1093/dnares/6.5.337. PMID 10574462.
- "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins.". Mol. Endocrinol. 14 (7): 1010–27. 2000. doi:10.1210/me.14.7.1010. PMID 10894151.
- "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors.". J. Biol. Chem. 277 (15): 12541–9. 2002. doi:10.1074/jbc.M112330200. PMID 11812797.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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