Biology:GOLGA1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Golgin subfamily A member 1 is a protein that in humans is encoded by the GOLGA1 gene.[1][2]
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein is associated with Sjogren's syndrome.[2]
Interactions
GOLGA1 has been shown to interact with ARL1.[3]
References
- ↑ "Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome". Arthritis and Rheumatism 40 (9): 1693–1702. September 1997. doi:10.1002/art.1780400920. PMID 9324025.
- ↑ 2.0 2.1 "Entrez Gene: GOLGA1 golgi autoantigen, golgin subfamily a, 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2800.
- ↑ "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell 14 (9): 3767–3781. September 2003. doi:10.1091/mbc.E03-01-0864. PMID 12972563.
Further reading
- "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins". Current Biology 9 (7): 381–384. April 1999. doi:10.1016/S0960-9822(99)80167-5. PMID 10209123. Bibcode: 1999CBio....9..381B.
- "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell 14 (9): 3767–3781. September 2003. doi:10.1091/mbc.E03-01-0864. PMID 12972563.
- "Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network". Molecular Biology of the Cell 15 (10): 4426–4443. October 2004. doi:10.1091/mbc.E03-12-0872. PMID 15269279.
- "The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers". The Biochemical Journal 388 (Pt 3): 835–841. June 2005. doi:10.1042/BJ20041810. PMID 15654769.
- "E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97". Traffic 6 (12): 1142–1156. December 2005. doi:10.1111/j.1600-0854.2005.00349.x. PMID 16262725.
- "A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis". Virology 362 (2): 421–427. June 2007. doi:10.1016/j.virol.2007.01.003. PMID 17276477.
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