Biology:GPHB5
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glycoprotein hormone beta-5 is a protein that in humans is encoded by the GPHB5 gene.[1]
GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM][1]
References
Z. Gong, W. Wang, K. El Omari, A. A. Lebedev, O. B. Clarke, W. A. Hendrickson, Crystal structure of LGR ligand alpha2/beta5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proc Natl Acad Sci U S A 120 (1), e2218630120 (2023). https://www.pnas.org/doi/10.1073/pnas.2218630120#
Further reading
- "A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor.". Mol. Endocrinol. 20 (2): 414–25. 2006. doi:10.1210/me.2005-0270. PMID 16210345.
- "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.". Endocrinology 146 (8): 3596–604. 2005. doi:10.1210/en.2005-0317. PMID 15890769.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. 2003. doi:10.1038/nature01348. PMID 12508121. Bibcode: 2003Natur.421..601H.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.". Mol. Endocrinol. 16 (7): 1538–51. 2003. doi:10.1210/mend.16.7.0871. PMID 12089349.
- "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor.". J. Clin. Invest. 109 (11): 1445–52. 2002. doi:10.1172/JCI14340. PMID 12045258.
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