Biology:GPR 120
GPR 120 is a G protein-coupled receptor (GPCR) and the putative receptor for omega-3 fatty acids including Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA).[1][2] GPR 120 was among a number of free fatty acid receptors only recently discovered from the human genome database utilizing the GPCR deorphanizing strategy.[3] Binding to the GPR 120 receptor is one of the many putative mechanisms of action for the potential health benefits of consuming omega-3 fatty acids. GPR 120 has specifically shown a role in the in-vivo anti-inflammatory and insulin-sensitizing effects of DHA and EPA in macrophages. Macrophage mediated inflammation is a key player in the pathophysiology of metabolic syndrome related disorders, including diabetes and atherosclerosis. GPR 120 is also a key regulator of adipogenesis, including adipocyte development and differentiation.[4]
References
- ↑ Oh, Da Young; Talukdar, Saswata; Bae, Eun Ju; Imamura, Takeshi; Morinaga, Hidetaka; Fan, Wuqiang; Li, Pingping; Lu, Wendell J. et al. (2010). "GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects". Cell 142 (5): 687–98. doi:10.1016/j.cell.2010.07.041. PMID 20813258.
- ↑ Miyauchi, Satoshi; Hirasawa, Akira; Iga, Tomoyo; Liu, Ning; Itsubo, Chisato; Sadakane, Keiko; Hara, Takafumi; Tsujimoto, Gozoh (2009). "Distribution and regulation of protein expression of the free fatty acid receptor GPR120". Naunyn-Schmiedeberg's Archives of Pharmacology 379 (4): 427–34. doi:10.1007/s00210-008-0390-8. PMID 19145429.
- ↑ Hirasawa, Akira; Hara, Takafumi; Katsuma, Susumu; Adachi, Tetsuya; Tsujimoto, Gozoh (2008). "Free Fatty Acid Receptors and Drug Discovery". Biological & Pharmaceutical Bulletin 31 (10): 1847–51. doi:10.1248/bpb.31.1847. PMID 18827341. http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/31.1847?from=PubMed.
- ↑ Gotoh, Chizu; Hong, Yeon-Hee; Iga, Tomoyo; Hishikawa, Daisuke; Suzuki, Yasuki; Song, Sang-Houn; Choi, Ki-Choon; Adachi, Tetsuya et al. (2007). "The regulation of adipogenesis through GPR120". Biochemical and Biophysical Research Communications 354 (2): 591–7. doi:10.1016/j.bbrc.2007.01.028. PMID 17250804.
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