Biology:GRAP2
 Generic protein structure example |
GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.[1][2][3]
Function
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.[3]
Interactions
GRAP2 has been shown to interact with:
- CCNDBP1,[4]
- CD28,[5]
- Linker of activated T cells,[2][6]
- Lymphocyte cytosolic protein 2[2][5][7][6]
- MAP4K1,[8] and
- STAMBP.[2][7]
References
- ↑ "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1". Biochemical and Biophysical Research Communications 253 (2): 443–7. Dec 1998. doi:10.1006/bbrc.1998.9795. PMID 9878555.
- ↑ 2.0 2.1 2.2 2.3 "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine 189 (9): 1383–90. May 1999. doi:10.1084/jem.189.9.1383. PMID 10224278.
- ↑ 3.0 3.1 "Entrez Gene: GRAP2 GRB2-related adaptor protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9402.
- ↑ "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". The Journal of Biological Chemistry 275 (27): 20942–8. Jul 2000. doi:10.1074/jbc.M002598200. PMID 10801854.
- ↑ 5.0 5.1 "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". Journal of Immunology 164 (11): 5805–14. Jun 2000. doi:10.4049/jimmunol.164.11.5805. PMID 10820259.
- ↑ 6.0 6.1 "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors". Current Biology 9 (2): 67–75. Jan 1999. doi:10.1016/s0960-9822(99)80017-7. PMID 10021361.
- ↑ 7.0 7.1 "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene 20 (14): 1703–14. Mar 2001. doi:10.1038/sj.onc.1204224. PMID 11313918.
Further reading
- "Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development". The EMBO Journal 17 (24): 7273–81. Dec 1998. doi:10.1093/emboj/17.24.7273. PMID 9857184.
- "Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc". Oncogene 17 (24): 3073–82. Dec 1998. doi:10.1038/sj.onc.1202337. PMID 9872323.
- "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors". Current Biology 9 (2): 67–75. Jan 1999. doi:10.1016/S0960-9822(99)80017-7. PMID 10021361.
- "GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation". The Journal of Experimental Medicine 189 (8): 1243–53. Apr 1999. doi:10.1084/jem.189.8.1243. PMID 10209041.
- "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. Dec 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". The Journal of Biological Chemistry 275 (27): 20942–8. Jul 2000. doi:10.1074/jbc.M002598200. PMID 10801854.
- "Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling". The Journal of Biological Chemistry 275 (30): 23355–61. Jul 2000. doi:10.1074/jbc.M000404200. PMID 10811803.
- "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". Journal of Immunology 164 (11): 5805–14. Jun 2000. doi:10.4049/jimmunol.164.11.5805. PMID 10820259.
- "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene 20 (14): 1703–14. Mar 2001. doi:10.1038/sj.onc.1204224. PMID 11313918.
- "The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes". The Journal of Biological Chemistry 276 (51): 48009–16. Dec 2001. doi:10.1074/jbc.M108941200. PMID 11641407.
- "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Letters 509 (2): 255–62. Dec 2001. doi:10.1016/S0014-5793(01)03174-X. PMID 11741599.
- "Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation". Molecular and Cellular Biology 22 (11): 3744–56. Jun 2002. doi:10.1128/MCB.22.11.3744-3756.2002. PMID 11997510.
- "Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters". Gene 290 (1–2): 173–9. May 2002. doi:10.1016/S0378-1119(02)00555-3. PMID 12062812.
- "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry 269 (13): 3279–88. Jul 2002. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.
- "Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling". The Journal of Biological Chemistry 277 (48): 46151–8. Nov 2002. doi:10.1074/jbc.M208946200. PMID 12359715.
- "Upstream open reading frames regulate translation of Mona/Gads adapter mRNA in the megakaryocytic lineage". Platelets 13 (8): 459–64. Dec 2002. doi:10.1080/0953710021000059431. PMID 12487779.
- "Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways". Journal of Immunology 170 (1): 349–55. Jan 2003. doi:10.4049/jimmunol.170.1.349. PMID 12496419.
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