Biology:Gadd7
| gadd7 | |
|---|---|
 Conserved secondary structure of gadd7 RNA | |
| Identifiers | |
| Symbol | gadd7 |
| Rfam | RF01800 |
| Other data | |
| RNA type | Gene |
| Domain(s) | Cricetulus |
| PDB structures | PDBe |
gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (Cricetulus griseus). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (C. longicaudatus).[1] Although the gene for this RNA contains open reading frames, translation studies found no protein product hence gadd7 has been classified as non-coding RNA.[2][3]
gadd7 was previously characterised as a hydrogen peroxide-inducible transcript[3] but has more recently been linked with lipotoxicity[1] - where the accumulation of lipids in non-adipose tissue brings about cell death.[4] gadd7 appears to be a key element in the lipotoxicty pathway, when it is knocked out the resulting mutant is much more resistant to oxidative stress.
The proposed mechanism for gadd7's role in lipotoxicity is:[1]
- The lipid palmitate builds to high concentration within a cell
- Reactive oxygen species (ROS) are generated
- This stress induces the expression of gadd7
- A feed-forward mechanism occurs
- ER stress brings about death of the cell
References
- ↑ 1.0 1.1 1.2 "The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress". J. Biol. Chem. 284 (12): 7446–7454. March 2009. doi:10.1074/jbc.M806209200. PMID 19150982. PMC 2658040. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=19150982. Retrieved 2010-07-23.
- ↑ "A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product". Nucleic Acids Res. 24 (9): 1589–1593. May 1996. doi:10.1093/nar/24.9.1589. PMID 8649973.
- ↑ 3.0 3.1 "Hydrogen peroxide induces the expression of adapt15, a novel RNA associated with polysomes in hamster HA-1 cells". Arch. Biochem. Biophys. 325 (2): 256–264. January 1996. doi:10.1006/abbi.1996.0032. PMID 8561505.
- ↑ Unger RH (2002). "Lipotoxic diseases". Annu. Rev. Med. 53: 319–336. doi:10.1146/annurev.med.53.082901.104057. PMID 11818477. http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.med.53.082901.104057?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov. Retrieved 2010-07-23.
Further reading
- "Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes". Cancer Res. 54 (21): 5656–5662. November 1994. PMID 7923213. http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=7923213. Retrieved 2010-07-23.
- "C-terminal end of v-src protein interacts with peptide coded by gadd7/adapt15-like RNA in two-hybrid system". FEBS Lett. 422 (1): 79–84. January 1998. doi:10.1016/S0014-5793(97)01568-8. PMID 9475174.
- "A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death". Mol. Biol. Cell 17 (2): 770–778. February 2006. doi:10.1091/mbc.E05-08-0742. PMID 16319173. PMC 1356587. http://www.molbiolcell.org/cgi/pmidlookup?view=long&pmid=16319173. Retrieved 2010-07-23.
- Mattick JS (April 2009). "The genetic signatures of noncoding RNAs". PLOS Genet. 5 (4): e1000459. doi:10.1371/journal.pgen.1000459. PMID 19390609.
- "adapt33, a novel oxidant-inducible RNA from hamster HA-1 cells". Arch. Biochem. Biophys. 332 (2): 255–260. August 1996. doi:10.1006/abbi.1996.0340. PMID 8806733.
- "Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death". J. Lipid Res. 47 (12): 2726–2737. December 2006. doi:10.1194/jlr.M600299-JLR200. PMID 16960261. http://www.jlr.org/cgi/pmidlookup?view=long&pmid=16960261. Retrieved 2010-07-23.
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