Biology:Gonadotropic cell
From HandWiki
| Gonadotropic cell | |
|---|---|
| Details | |
| System | Reproductive system |
| Location | Anterior pituitary gland |
| Function | Gonadotropin secretion (follicle-stimulating hormone (FSH) and luteinizing hormone (LH)) |
| Anatomical terms of microanatomy | |
Gonadotropic cells (called also Gonadotropes or Gonadotrophs or Delta Cells or Delta basophils)[1] are endocrine cells in the anterior pituitary that produce the gonadotropins, such as the follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Release of FSH and LH by gonadotropes is regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus.[2]
Gonadotropes appear basophilic in histological preparations.
Gonadotropes have insulin receptors, which can be overstimulated by too high insulin levels. This may lead to infertility as hormone release levels are disrupted.[3][4]
Gonadotropes are feedback inhibited by specific hormones, including estradiol.[5]
See also
- List of human cell types derived from the germ layers
- List of distinct cell types in the adult human body
References
- ↑ DOUGLAS, ANDERSON (2012). Dorland's Illustrated Medical Dictionary, 32 edition. USA: Elsevier. pp. 797. ISBN 978-1-4160-6257-8.
- ↑ Ganong, William F.: "Review of Medical Physiology", page 248. Lange, 2005.
- ↑ Brothers, K. J.; Wu, S.; Divall, S. A.; Messmer, M. R.; Kahn, C. R.; Miller, R. S.; Radovick, S.; Wondisford, F. E. et al. (2010). "Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor (IR)". Cell Metabolism 12 (3): 295–305. doi:10.1016/j.cmet.2010.06.010. PMID 20816095.
- ↑ "Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.". Cell Metabolism 11 (4): 286–97. 2010. doi:10.1016/j.cmet.2010.03.002. PMID 20374961.
- ↑ Iqbal, Javed; Latchoumanin, Olivier; Sari, Ika P.; Lang, Richard J.; Coleman, Harold A.; Parkington, Helena C.; Clarke, Iain J. (2009-09-01). "Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release". Endocrinology 150 (9): 4213–4220. doi:10.1210/en.2009-0092. ISSN 1945-7170. PMID 19477939.
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