Biology:Goodpasture-antigen-binding protein kinase
| Goodpasture-antigen-binding protein kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.11.9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, a Goodpasture-antigen-binding protein kinase (EC 2.7.11.9) is an enzyme that catalyzes the chemical reaction
- ATP + Goodpasture antigen-binding protein [math]\displaystyle{ \rightleftharpoons }[/math] ADP + [Goodpasture antigen-binding phosphoprotein]
Thus, the two substrates of this enzyme are ATP and Goodpasture antigen-binding protein, whereas its two products are ADP and Goodpasture antigen-binding phosphoprotein.
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[Goodpasture antigen-binding protein] phosphotransferase. Other names in common use include GPBPK, GPBP kinase, STK11, and Goodpasture antigen-binding protein kinase. This enzyme participates in mTOR signaling pathway and adipocytokine signaling pathway.
References
- "Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen". J. Biol. Chem. 274 (18): 12642–9. 1999. doi:10.1074/jbc.274.18.12642. PMID 10212244.
- "Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis". J. Biol. Chem. 275 (51): 40392–9. 2000. doi:10.1074/jbc.M002769200. PMID 11007769.
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