Biology:HERC3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
| HERC3 | |
|---|---|
| Identifiers | |
| Symbol | HERC3 |
| Alt. names | HECT domain and RCC1-like domain-containing protein 3, HECT-type E3 ubiquitin transferase HERC3, KIAA0032 |
| NCBI gene | 8916 |
| HGNC | 4876 |
| OMIM | 605200 |
| PDB | Q15034 |
| RefSeq | NM_001271602, NM_001318505&rn=1 NM_014606, NM_001271602, NM_001318505 |
| UniProt | Q15034 |
| Other data | |
| EC number | 2.3.2.26 |
| Locus | Chr. 4 q22.1:88,592,422-88,709,302 |
Probable E3 ubiquitin-protein ligase HERC3 is an enzyme that in humans is encoded by the HERC3 gene.[1][2] The gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and an RCC1-like domain (RLD). It binds ubiquitin and hPLIC-1/2 via its HECT domain. Alternatively spiced transcript variants encoding multiple isoforms have been observed, and mutations in this gene have been linked to colorectal and gastric carcinomas. The protein is localized in the cytosol and vesicular-like structures containing β-COP, ARF, and Rab5. Since HERC3 can itself be ubiquitinated and degraded by the proteasome, it likely has roles in both vesicular traffic and ubiquitin-dependent processes.[3][4][5]
References
- ↑ "The HERC proteins: functional and evolutionary insights". Cell Mol Life Sci 62 (16): 1826–1838. Aug 2005. doi:10.1007/s00018-005-5119-y. PMID 15968461.
- ↑ "Functional and pathological relevance of HERC family proteins: a decade later". Cell Mol Life Sci 73 (10): 18955–1968. May 2016. doi:10.1007/s00018-016-2139-8. PMID 26801221.
- ↑ "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell Mol Life Sci 65 (13): 2105–2117. Jul 2008. doi:10.1007/s00018-008-8148-5. PMID 18535780.
- ↑ "HERC3 binding to and regulation by ubiquitin". FEBS Lett 488 (1–2): 74–80. Jan 2001. doi:10.1016/S0014-5793(00)02371-1. PMID 11163799.
- ↑ "Entrez Gene: HERC3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8916.
Further reading
- "The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation". Nucleic Acids Res 43 (20): 9889–9904. 16 Nov 2015. doi:10.1093/nar/gkv1064. PMID 26476452.
- "Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus". Nucleic Acids Res 40 (18): 8917–8926. Oct 2012. doi:10.1093/nar/gks654. PMID 22790983.
- "Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability". Pathology 43 (7): 753–755. Dec 2011. doi:10.1097/PAT.0b013e32834c7e78. PMID 22124266.
- "HECT E3s and human disease". BMC Biochem 8 ((Suppl 1):S6): S6. 22 Nov 2007. doi:10.1186/1471-2091-8-S1-S6. PMID 18047743.
- "The human HERC3 gene maps to chromosome 4q21 by fluorescence in situ hybridization". Cytogenet Cell Genet 87 (3–4): 263–264. 1999. doi:10.1159/000015442. PMID 10702688.
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