Biology:HEXIM1
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Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene.[1][2][3]
Interactions
HEXIM1 has been shown to interact with Cyclin T1[2] and Cdk9[4]
References
- ↑ "Structure, expression, and functional characterization of the mouse CLP-1 gene". Gene 292 (1–2): 245–59. Jul 2002. doi:10.1016/S0378-1119(02)00596-6. PMID 12119119.
- ↑ 2.0 2.1 "MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner". Mol Cell Biol 23 (14): 4859–69. Jun 2003. doi:10.1128/MCB.23.14.4859-4869.2003. PMID 12832472.
- ↑ "Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10614.
- ↑ "An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb". Proc Natl Acad Sci U S A 113 (45): 12721–6. October 2016. doi:10.1073/pnas.1612331113. PMID 27791144.
Further reading
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells". Genes Cells 8 (2): 95–107. 2003. doi:10.1046/j.1365-2443.2003.00618.x. PMID 12581153.
- "Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors". Cancer Res. 63 (16): 5151–8. 2003. PMID 12941847.
- "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA". Mol. Cell 12 (4): 971–82. 2003. doi:10.1016/S1097-2765(03)00388-5. PMID 14580347.
- "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell 117 (3): 311–21. 2004. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492.
- "A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb". Mol. Cell. Biol. 24 (12): 5094–105. 2004. doi:10.1128/MCB.24.12.5094-5105.2004. PMID 15169877.
- "Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor". EMBO J. 23 (13): 2608–19. 2005. doi:10.1038/sj.emboj.7600275. PMID 15201869.
- "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription". J. Biol. Chem. 280 (16): 16368–76. 2005. doi:10.1074/jbc.M500912200. PMID 15713661.
- "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK". J. Biol. Chem. 280 (16): 16360–7. 2005. doi:10.1074/jbc.M500424200. PMID 15713662.
- "Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat". J. Biol. Chem. 280 (26): 24968–77. 2005. doi:10.1074/jbc.M501431200. PMID 15855166.
- "The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1". Oncogene 24 (36): 5576–88. 2005. doi:10.1038/sj.onc.1208728. PMID 15940264.
- "HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8555–60. 2005. doi:10.1073/pnas.0409863102. PMID 15941832. Bibcode: 2005PNAS..102.8555S.
- "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186". J. Biol. Chem. 280 (31): 28819–26. 2005. doi:10.1074/jbc.M502712200. PMID 15965233.
- "Inhibition of Tat activity by the HEXIM1 protein". Retrovirology 2: 42. 2006. doi:10.1186/1742-4690-2-42. PMID 15992410.
- "Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer". J. Biol. Chem. 280 (34): 30619–29. 2005. doi:10.1074/jbc.M502471200. PMID 15994294.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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