Biology:HGS (gene)
From HandWiki
 Generic protein structure example |
Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.[1][2][3]
Interactions
HGS has been shown to interact with:
- CLTC[4]
- DLG4,[5]
- EPS15,[6][7]
- IL2RB,[8]
- Merlin,[9][10]
- STAM2,[6][11]
- Signal transducing adaptor molecule[1][6][11]
- TSG101.[11][12]
References
- ↑ 1.0 1.1 Asao, H.; Sasaki, Y.; Arita, T.; Tanaka, N.; Endo, K.; Kasai, H.; Takeshita, T.; Endo, Y. et al. (1997). "Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule: Its suppressive effect on cytokine-induced cell growth". Journal of Biological Chemistry 272 (52): 32785–32791. doi:10.1074/jbc.272.52.32785. ISSN 0021-9258. PMID 9407053.
- ↑ "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene 213 (1–2): 125–32. August 1998. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.
- ↑ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9146.
- ↑ "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. September 2001. doi:10.1093/emboj/20.17.5008. PMID 11532964.
- ↑ "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". J. Neurosci. 22 (15): 6415–25. August 2002. doi:10.1523/JNEUROSCI.22-15-06415.2002. PMID 12151521.
- ↑ 6.0 6.1 6.2 "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14): 12513–21. April 2003. doi:10.1074/jbc.M210843200. PMID 12551915.
- ↑ "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. May 2000. doi:10.1074/jbc.275.20.15271. PMID 10809762.
- ↑ "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell Sci. 121 (Pt 10): 1727–38. May 2008. doi:10.1242/jcs.024455. PMID 18445679.
- ↑ "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. April 2001. doi:10.1093/hmg/10.8.825. PMID 11285248.
- ↑ "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. July 2000. doi:10.1093/hmg/9.11.1567. PMID 10861283.
- ↑ 11.0 11.1 11.2 "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7626–31. June 2003. doi:10.1073/pnas.0932599100. PMID 12802020.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)
Further reading
- "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells". EXS 65: 131–65. 1993. PMID 8380735.
- "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes". J. Biol. Chem. 272 (33): 20538–44. 1997. doi:10.1074/jbc.272.33.20538. PMID 9252367.
- "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. 1999. doi:10.1074/jbc.274.42.30080. PMID 10514494.
- "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. 2000. doi:10.1074/jbc.275.20.15271. PMID 10809762.
- "Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis". J. Cell Sci. 113 (12): 2273–84. 2000. doi:10.1242/jcs.113.12.2273. PMID 10825299. https://cdr.lib.unc.edu/downloads/f1881w24k.
- "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. 2000. doi:10.1093/hmg/9.11.1567. PMID 10861283.
- "Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells". EMBO J. 19 (17): 4577–88. 2000. doi:10.1093/emboj/19.17.4577. PMID 10970851.
- "Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA". Mol. Cell. Biol. 20 (24): 9346–55. 2000. doi:10.1128/MCB.20.24.9346-9355.2000. PMID 11094085.
- "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor". J. Biol. Chem. 276 (10): 7069–78. 2001. doi:10.1074/jbc.M004129200. PMID 11110793.
- "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. 2001. doi:10.1093/hmg/10.8.825. PMID 11285248.
- "Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1". J. Biol. Chem. 276 (32): 29943–52. 2001. doi:10.1074/jbc.M104230200. PMID 11397816.
- "FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes". J. Cell Sci. 114 (Pt 12): 2255–63. 2001. doi:10.1242/jcs.114.12.2255. PMID 11493665.
- "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. 2001. doi:10.1093/emboj/20.17.5008. PMID 11532964.
- "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway". J. Biol. Chem. 277 (2): 1031–9. 2002. doi:10.1074/jbc.M109992200. PMID 11687594.
- "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates". J. Cell Biol. 157 (1): 91–101. 2002. doi:10.1083/jcb.200112080. PMID 11916981.
- "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. 2002. doi:10.1007/BF03402003. PMID 11984006.
- "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking". J. Biol. Chem. 277 (31): 28212–21. 2002. doi:10.1074/jbc.M111612200. PMID 12021262.
 |
