Biology:HIST1H2AE

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AE gene.^[1]^[2]^[3]^[4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4).

The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.^[4]

References

↑ "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. Apr 1997. doi:10.1006/geno.1996.4592. PMID 9119399.
↑ "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics 10 (4): 940–8. Nov 1991. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
↑ "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. Oct 2002. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
↑ ^4.0 ^4.1 "Entrez Gene: HIST1H2AE histone cluster 1, H2ae". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3012.

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