Biology:HIST1H4C

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Histone H4 is a protein that in humans is encoded by the HIST1H4C gene.

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Further reading

• "Association of histone H4 genes with the mammalian testis-specific H1t histone gene". DNA Cell Biol. 14 (7): 591–7. 1995. doi:10.1089/dna.1995.14.591. PMID 7626218. 
• "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. 1998. doi:10.1007/s004390050630. PMID 9439656. 
• "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. 1998. doi:10.1128/mcb.18.5.2535. PMID 9566873. 
• "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology 277 (2): 278–95. 2001. doi:10.1006/viro.2000.0593. PMID 11080476. 
• "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology 289 (2): 312–26. 2001. doi:10.1006/viro.2001.1129. PMID 11689053. 
• "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. 2004. doi:10.1093/emboj/cdg631. PMID 14657027. 
• "Arresting cancer proliferation by small-molecule gene regulation". Chem. Biol. 11 (11): 1583–94. 2005. doi:10.1016/j.chembiol.2004.09.004. PMID 15556009.