Biology:HIST1H4D
 Generic protein structure example |
Histone H4 is a protein that in humans is encoded by the HIST1H4D gene.[1][2][3]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]
References
- ↑ "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. Apr 1997. doi:10.1006/geno.1996.4592. PMID 9119399.
- ↑ "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. Oct 2002. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
- ↑ 3.0 3.1 "Entrez Gene: HIST1H4D histone cluster 1, H4d". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8360.
Further reading
- "Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene". Science 236 (4806): 1308–11. 1987. doi:10.1126/science.3035717. PMID 3035717. Bibcode: 1987Sci...236.1308P.
- "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. 1998. doi:10.1007/s004390050630. PMID 9439656.
- "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. 1998. doi:10.1128/mcb.18.5.2535. PMID 9566873.
- "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology 277 (2): 278–95. 2001. doi:10.1006/viro.2000.0593. PMID 11080476.
- "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology 289 (2): 312–26. 2001. doi:10.1006/viro.2001.1129. PMID 11689053.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. 2004. doi:10.1093/emboj/cdg631. PMID 14657027.
- "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. 2005. doi:10.1074/jbc.M403080200. PMID 15504738.
External links
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