Biology:HIV-2 protease

From HandWiki
HIV-2 retropepsin
Identifiers
EC number3.4.23.47
CAS number144114-21-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

HIV-2 protease or retropepsin (EC 3.4.23.47) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Endopeptidase for which the P1 residue is preferably hydrophobic

This enzyme belongs to the peptidase family A2.

References

  1. "Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins". FEBS Letters 281 (1-2): 77–80. April 1991. doi:10.1016/0014-5793(91)80362-7. PMID 2015912. 
  2. "Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases". The Journal of Biological Chemistry 269 (42): 26344–8. October 1994. PMID 7929352. 

External links