Biology:HLA-DOA

Generic protein structure example

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

Further reading

• "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics 34 (2): 121–8. 1991. doi:10.1007/BF00211424. PMID 1869305. 
• "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. 1990. PMID 1967269. 
• "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. 1991. doi:10.1073/pnas.87.22.9052. PMID 1978941. 
• "An unusual form of alternative splicing in the HLA-DNA gene". Immunogenetics 33 (2): 124–31. 1991. doi:10.1007/BF00210826. PMID 1999352. 
• "Human class II DNA and DOB genes display low sequence variability". Immunogenetics 29 (6): 411–3. 1989. doi:10.1007/BF00375872. PMID 2499532. 
• "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature 339 (6225): 548–51. 1989. doi:10.1038/339548a0. PMID 2543930. 
• "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. 1988. PMID 2846691. 
• "Isolation and characterization of the cDNA clone and genomic clones of a new HLA class II antigen heavy chain, DO alpha". J. Immunol. 135 (3): 2156–9. 1985. PMID 2991382. 
• "The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions". EMBO J. 4 (9): 2231–7. 1986. doi:10.1002/j.1460-2075.1985.tb03919.x. PMID 3000765. 
• "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications". AIDS Research 2 (3): 163–74. 1986. doi:10.1089/aid.1.1986.2.163. PMID 3489470. 
• "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475–88. 1994. PMID 7512597. 
• "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. 1995. PMID 7541827. 
• "Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC". J. Immunol. 155 (1): 473–88. 1995. PMID 7602119. 
• "HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41". Mol. Immunol. 31 (13): 977–82. 1994. doi:10.1016/0161-5890(94)90092-2. PMID 8084338. 
• "Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help". Cell. Immunol. 155 (1): 169–82. 1994. doi:10.1006/cimm.1994.1110. PMID 8168144. 
• "HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes". J. Immunol. 151 (6): 2928–42. 1993. PMID 8376762. 
• "HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport". EMBO J. 15 (18): 4817–24. 1996. doi:10.1002/j.1460-2075.1996.tb00862.x. PMID 8890155. 
• "The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway". J. Biol. Chem. 272 (13): 8671–8. 1997. doi:10.1074/jbc.272.13.8671. PMID 9079699. 
• "HLA-DO is an intracellular class II molecule with distinctive thymic expression". Int. Immunol. 9 (3): 355–64. 1997. doi:10.1093/intimm/9.3.355. PMID 9088974.