Biology:HLA-DR9
From HandWiki
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human major histocompatibility complex, class II, DR9
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| Haplotypes groups | DQA*01:DRB1*0901 to
DQA*01:DRB1*0906 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
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| Symbol(s) | HLA-DRA[yes|permanent dead link|dead link}}] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *0901
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| Symbol(s) | HLA-DRB1[yes|permanent dead link|dead link}}] |
| EBI-HLA | DRB1*0901 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR09 (DR9) is a HLA-DR serotype that recognizes the DRB1*0901 gene product.
Serology
| DRB1* | DR9 | Sample | ||
| allele | % | % | % | size (N) |
| 0901 | 95 | 1058 |
The serological reaction of DR9 is relatively good. The serology of DRB1*0902 to *0906 serotypes is unknown.
Disease associations
DRB1*0901: Early childhood myasthenia gravis[2]
Extended linkage
DRB1*0901:DQA1*0301:DQB1*0303 haplotype: Early childhood myastenia gravis[2]
Genetic linkage
DR09 Haplotypes
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| DRA | DRB1 | ||
|---|---|---|---|
| Haplotypes | *0101 | *0901 | *0101 |
| DQA1 | DQB1 | DRB1 | |
| Haplotypes | *0301 | *0303 | *0901 |
| HLA-A | HLA-B | DRB1 | |
| Haplotypes | *0000 | *0000 | *0901 |
HLA-DR9 is genetically linked to HLA-DR53, and HLA-DQ3 and DQ9 serotypes.
References
- ↑ derived from IMGT/HLA
- ↑ 2.0 2.1 "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan.". Clin Immunol 110 (2): 154–8. 2004. doi:10.1016/j.clim.2003.10.004. PMID 15003812.
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