Biology:HTH-XRE RNA motif
From HandWiki
| HTH-XRE | |
|---|---|
 Consensus secondary structure and sequence conservation of HTH-XRE RNA | |
| Identifiers | |
| Symbol | HTH-XRE |
| Rfam | RF02923 |
| Other data | |
| RNA type | Cis-reg |
| SO | 0005836 |
| PDB structures | PDBe |
The HTH-XRE RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] HTH-XRE motifs are found in Clostridiales.
HTH-XRE RNAs are often found upstream of genes encoding proteins with the XRE-like helix-turn-helix protein domain. However, in many cases, HTH-XRE RNAs are not upstream of a protein-coding gene. Additionally, genes encoding XRE-like domains are extremely common in bacteria, so it is possible that the association between this protein domain and the HTH-XRE RNA arises purely by coincidence. Overall, it is ambiguous whether HTH-XRE RNAs function as cis-regulatory elements or whether they operate in trans as small RNAs.
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
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