Biology:HUWE1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.[1][2][3]
It performs the third step (ligation) in binding ubiquitin to proteins in a process called ubiquitination which tags the proteins for disposal.
Human genetic studies that implicate HUWE1 in intellectual disability.[4] Additional research suggests HUWE1 has implications in cancer research.
References
- ↑ "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 4 (2): 141–50. April 1997. doi:10.1093/dnares/4.2.141. PMID 9205841.
- ↑ "The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases". Trends in Cell Biology 10 (10): 429–39. October 2000. doi:10.1016/S0962-8924(00)01834-1. PMID 10998601.
- ↑ "Entrez Gene: HUWE1 HECT, UBA and WWE domain containing 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10075.
- ↑ "Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease". Neural Development 15 (1). April 2020. doi:10.1186/s13064-020-00143-9. PMID 32336296.
Further reading
- "UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation". Oncogene 11 (10): 2175–8. November 1995. PMID 7478539.
- "Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene". Brain Research. Molecular Brain Research 24 (1–4): 77–88. July 1994. doi:10.1016/0169-328X(94)90120-1. PMID 7968380. https://zenodo.org/record/1258413.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (4): 273–81. August 2000. doi:10.1093/dnares/7.4.271. PMID 10997877.
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research 10 (10): 1546–60. October 2000. doi:10.1101/gr.140200. PMID 11042152.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. August 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein". Biochemical and Biophysical Research Communications 326 (1): 7–17. January 2005. doi:10.1016/j.bbrc.2004.11.004. PMID 15567145.
- "Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones". Molecular and Cellular Biology 25 (7): 2819–31. April 2005. doi:10.1128/MCB.25.7.2819-2831.2005. PMID 15767685.
- "ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor". Cell 121 (7): 1071–83. July 2005. doi:10.1016/j.cell.2005.03.037. PMID 15989956.
- "Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis". Cell 121 (7): 1085–95. July 2005. doi:10.1016/j.cell.2005.06.009. PMID 15989957.
- "BH3-ligand regulates access of MCL-1 to its E3 ligase". FEBS Letters 579 (25): 5603–8. October 2005. doi:10.1016/j.febslet.2005.09.028. PMID 16213503. Bibcode: 2005FEBSL.579.5603W.
- "The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation". Cell 123 (3): 409–21. November 2005. doi:10.1016/j.cell.2005.08.016. PMID 16269333. http://nbn-resolving.de/urn:nbn:de:bsz:352-167715.
External links
- HUWE1 human gene location in the UCSC Genome Browser.
- International HUWE1 Community: www.huwe1.org
- Community Italiana Huwe1https://huwe1italia.wordpress.com/[1]
- Louie's HUWE - a US 501c3 nonprofit to support people with HUWE1-related genetic conditions: www.huwe1.org/louieshuwe
- HUWE1 human gene details in the UCSC Genome Browser.
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