Biology:Haplogroup P1 (Y-DNA)
| Haplogroup P1 (also known as P-M45; K2b2a) | |
|---|---|
| Possible time of origin | ~38,000 BCE |
| Possible place of origin | Central Asia or Siberia [1][2][3] |
| Ancestor | P (P-P295)[4] |
| Descendants | Q (Q-M242) and R (R-M207). |
| Defining mutations | M45/PF5962 |
Haplogroup P1, also known as P-M45 and K2b2a, is a Y-chromosome DNA haplogroup in human genetics. Defined by the SNPs M45 and PF5962, P1 is a primary branch (subclade) of P (P-P295; K2b2).
The only primary subclades of P1 are Haplogroup Q (Q-M242) and Haplogroup R (R-M207). These haplogroups now comprise most of the male lineages among Native Americans, Europeans, Central Asia and South Asia, among other parts of the world.
P1 (M45) likely originated in Central Asia or Siberia,[2][1] with basal P1* (P1xQ,R) now most common among individuals in Siberia and Central Asia.[5][3][1][6][2] A 2018 study found basal P1* in two Siberian individuals dated to the Upper Paleolithic (~31,630 cal BP) from a Yana river archaeological site known as Yana RHS.[7] P-P226, which forms the parent clade of Q and R, has been found among a 33,000 year old human specimen (AR33K), who displayed close genetic affinity to the 40,000 year old Tianyuan man from northern China who belonged to the upstream K2b clade, and which contributed to the formation of Ancient North Eurasian, but went extinct as own lineage.[8][9][10]
Structure
The subclades of Haplogroup P1 with their defining mutation, according to the 2016 ISOGG tree:[6]
- P1 (M45/PF5962)
Ancient and modern distribution
P1*
The modern populations with high frequencies of P1* (or P1xQ,R) are located in Central Asia and Eastern Siberia:
- 35.4% among Tuvan males;
- 35% among Nivkh and;
- 28.3% among Altai-Kizhi.[5]
Modern South Asian populations also feature P1 (M45) at low to moderate frequencies.[11] In South Asia, P-M45 is most frequent among the Muslims of Manipur (Pangal, 33%), but this may be due to a very small sample size (nine individuals).
A levels of 14% P-M45* on the island of Korčula in Dalmatia (modern Croatia) and 6% on the neighbouring island of Hvar, may be linked to immigration during the early medieval period, by Central Asian peoples such as the Avars.[12]
It is possible that many cases of haplogroup P1 reported in Central Asia, South Asia and/or West Asia are members of rare or less-researched subclades of haplogroups R2 and Q, rather than P1* per se.
| Population group | Language family | Citation | Sample size | Percentage | Comments |
|---|---|---|---|---|---|
| Tuvinian | Turkic | Darenko 2005 | 113 | 35.40 | P-M45 |
| Nivkh | Nivkh | Lell 2001 | 17 | 35 | P-M45 |
| Altai-Kizhi | Turkic | Darenko 2005 | 92 | 28.3 | P-M45 |
| Todjin | Turkic | Darenko 2005 | 36 | 22.2 | P-M45 |
| Chukchi | Chukotko-Kamchatkan | Lell 2001 | 24 | 20.8 | P-M45 |
| Koryak | Chukotko-Kamchatkan | Lell 2001 | 27 | 18.5 | P-M45 |
| Yupik | Eskimo–Aleut languages | Lell 2001 | 33 | 18.2 | P-M45 |
| Uighur | Turkic | Xue 2006 | 70 | 17.1 | P-M45 |
| Kalmyk | Mongolic | Darenko 2005 | 68 | 11.8 | P-M45 |
| Turkmen | Turkic | Wells 2001 | 30 | 10 | P-M45 |
| Soyot | Turkic | Darenko 2005 | 34 | 8.8 | P-M45 |
| Uriankhai | Mongolic | Katoh 2004 | 60 | 8.3 | P-M45 |
| Khakas | Turkic | Darenko 2005 | 53 | 7.6 | P-M45 |
| Kazakh | Turkic | Wells 2001 | 54 | 5.6 | P-M45 |
| Uzbek | Turkic | Wells 2001 | 366 | 5.5 | P-M45 |
| Khasi-Khmuic | Austroasiatic | Reddy 2009 | 353 | 5.40 | P-M45(xM173)§ |
| Munda | Austroasiatic | Reddy 2009 | 64 | 10.90 | P-M45(xM173)§ |
| Nicobarese | Mon-Khmer | Reddy 2009 | 11 | 0.00 | P-M45(xM173)§ |
| South-East Asia | Austroasiatic | Reddy 2009 | 257 | 1.60 | P-M45(xM173)§ |
| Garo | Tibeto-Burman | Reddy 2009 | 71 | 1.40 | P-M45(xM173)§ |
| North-east India | Tibeto-Burman | Reddy 2009 | 226 | 3.10 | P-M45(xM173)§ |
| East Asia | Tibeto-Burman | Reddy 2009 | 214 | 0.00 | P-M45(xM173)§ |
| Eastern India | various/unknown | Reddy 2009 | 54 | 18.50 | P-M45(xM173)§ |
| Southern Talysh (Iran) | Iranian | Nasidze 2009 | 50 | 4.00 | P-M45(xM124,xM173) |
| Northern Talysh (Azerbaijan) | Iranian | Nasidze 2009 | 40 | 5.00 | P-M45(xM124,xM173) |
| Mazandarani | Iranian | Nasidze 2009 | 50 | 4.00 | P-M45(xM124,xM173) |
| Gilaki | Iranian | Nasidze 2009 | 50 | 0.00 | P-M45(xM124,xM173) |
| Tehran | Iranian | Nasidze 2004 | 80 | 4.00 | P-M45(xM124,xM173) |
| Isfahan | Iranian | Nasidze 2004 | 50 | 6.00 | P-M45(xM124,xM173) |
| Bakhtiari | Iranian | Nasidze 2008 | 53 | 2.00 | P-M45(xM124,xM173) |
| Iranian Arabs | Arabic | Nasidze 2008 | 47 | 2.00 | P-M45(xM124,xM173) |
| North Iran | Iranian | Regueiro 2006 | 33 | 9.00 | P-M45(xM124,xM173) |
| South Iran | Iranian | Regueiro 2006 | 117 | 3.00 | P-M45(xM124,xM173) |
| South Caucacus | Georgian | Nasidze and Stoneking 2001 | 77 | 3.00 | P-M45(xM124,xM173) |
| South Caucacus | Armenian | Nasidze and Stoneking 2001 | 100 | 2.00 | P-M45(xM124,xM173) |
| Sherpas from Nepal | Tibeto-Burman | Bhandari et al. 2015 | 582 | 1.67 | P1(M45) or P(xQ,R1a1,R1b,R2)† |
| Sherpas from Tibet | Tibeto-Burman | Bhandari et al. 2015 | 582 | 0.64 | P1(M45) or P(xQ,R1a1,R1b,R2)† |
| Hvar (Dalmatian Islands) | Croatian | Barać et al. 2003 | 14 | Possible link to medieval Avar settlers.[12] | |
| Korčula (Dalmatian Islands) | Croatian | Barać et al. 2003 | 6 | Possible link to medieval Avar settlers.[12] |
§ May include members of haplogroup R2.
† May include members of haplogroup R1*/R1a*
| Population group | N | P (xQ,xR) | Q | R | Paper | |||
|---|---|---|---|---|---|---|---|---|
| Count | % | Count | % | Count | % | |||
| Gope | 16 | 1 | 6.4 | Sahoo 2006 | ||||
| Oriya Brahmin | 24 | 1 | 4.2 | Sahoo 2006 | ||||
| Mahishya | 17 | 3 | 17.6 | Sahoo 2006 | ||||
| Bhumij | 15 | 2 | 13.3 | Sahoo 2006 | ||||
| Saora | 13 | 3 | 23.1 | Sahoo 2006 | ||||
| Nepali | 7 | 2 | 28.6 | Sahoo 2006 | ||||
| Muslims of Manipur | 9 | 3 | 33.3 | Sahoo 2006 | ||||
| 15 | 1 | 6.7 | Sahoo 2006 | |||||
| Lambadi | 18 | 4 | 22.2 | Sahoo 2006 | ||||
| Gujarati Patel | 9 | 2 | 22.2 | Sahoo 2006 | ||||
| Katkari | 19 | 1 | 5.3 | Sahoo 2006 | ||||
| Madia Gond | 14 | 1 | 7.1 | Sahoo 2006 | ||||
| Kamma Chowdary | 15 | 0 | 0 | 1 | 6.7 | 12 | 80 | Sahoo 2006 |
Q
Near universal in the Kets (95%) of Siberia. Very common in pre-modern Native American populations, except for the Na-Dene peoples, where it reaches 50-90%.
Also common, at 25-50%, in modern Siberian populations such as the Nivkhs, Selkups, Tuvans, Chukchi, Siberian Eskimos, Northern Altaians, and in 30% of Turkmens.
R
The only discovered case of basal R* (i.e. one that does not belong to R1 or R2) is the Mal'ta Boy.
Subclades of R1b, R1a and R2 are now dominant in various populations from Europe to South Asia.
References
- ↑ 1.0 1.1 1.2 Tumonggor, Karafet et al., 2014, "Isolation, contact and social behavior shaped genetic diversity in West Timor", Journal of Human Genetics Vol. 59, No. 9 (September), pp. 494–503.
- ↑ 2.0 2.1 2.2 E. Heyer et al., 2013, "Genetic Diversity of Four Filipino Negrito Populations from Luzon: Comparison of Male and Female Effective Population Sizes and Differential Integration of Immigrants into Aeta and Agta Communities", Human Biology, Vol. 85, Iss. 1, p. 201.
- ↑ 3.0 3.1 Tatiana M Karafet (2015). "Improved phylogenetic resolution and rapid diversification of Y-chromosome haplogroup K-M526 in Southeast Asia". European Journal of Human Genetics 23 (3): 369–373. doi:10.1038/ejhg.2014.106. PMID 24896152.
- ↑ "Generation of high-resolution a priori Y-chromosome phylogenies using "next-generation" sequencing data". 2013-11-22. bioRxiv 10.1101/000802.
- ↑ 5.0 5.1 Miroslava Derenko et al 2005, Contrasting patterns of Y-chromosome variation in South Siberian populations from Baikal and Altai-Sayan regions Zgms.cm.umk.pl
- ↑ 6.0 6.1 ISOGG (2016). "Y-DNA Haplogroup P". http://isogg.org/tree/ISOGG_HapgrpP.html.
- ↑ Sikora, Martin; Pitulko, Vladimir; Sousa, Vitor; Allentoft, Morten E.; Vinner, Lasse; Rasmussen, Simon; Margaryan, Ashot; Damgaard, Peter de Barros et al. (2018-10-22). "The population history of northeastern Siberia since the Pleistocene" (in en). bioRxiv: 448829. doi:10.1101/448829. https://www.biorxiv.org/content/early/2018/10/22/448829.
- ↑ Mao, Xiaowei; Zhang, Hucai; Qiao, Shiyu; Liu, Yichen; Chang, Fengqin; Xie, Ping; Zhang, Ming; Wang, Tianyi et al. (June 2021). "The deep population history of northern East Asia from the Late Pleistocene to the Holocene". Cell 184 (12): 3256–3266.e13. doi:10.1016/j.cell.2021.04.040. ISSN 0092-8674. https://doi.org/10.1016/j.cell.2021.04.040.
- ↑ Estes, Roberta (2020-09-12). "Y DNA Haplogroup P Gets a Brand-New Root – Plus Some Branches" (in en-US). https://dna-explained.com/2020/09/12/y-dna-haplogroup-p-gets-a-brand-new-root-plus-some-branches/.
- ↑ "Allen Ancient DNA Resource (AADR): Downloadable genotypes of present-day and ancient DNA data | David Reich Lab". https://reich.hms.harvard.edu/allen-ancient-dna-resource-aadr-downloadable-genotypes-present-day-and-ancient-dna-data.
- ↑ Sahoo, S. (2006). "A prehistory of Indian Y chromosomes: Evaluating demic diffusion scenarios". Proceedings of the National Academy of Sciences 103 (4): 843–8. doi:10.1073/pnas.0507714103. PMID 16415161. Bibcode: 2006PNAS..103..843S.
- ↑ 12.0 12.1 12.2 Paolo Francalacci & Daria Sanna, "History and geography of human Y-chromosome in Europe: a SNP perspective", Journal of Anthropological Sciences, vol. 86 (2008), pp. 59-89. [Access: Aug 24, 2017].)
Sources
- Barać (2003). "Y chromosomal heritage of Croatian population and its island isolates". European Journal of Human Genetics 11 (7): 535–542. doi:10.1038/sj.ejhg.5200992. PMID 12825075. http://evolutsioon.ut.ee/publications/Barac2003.pdf.
External links
- Spread of Haplogroup P, from The Genographic Project, National Geographic
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