Biology:Heme ligase
From HandWiki
| Heme ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.99.1.8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (β-hematin-forming).[1] This enzyme catalyses the following reaction:
- 2 ferriprotoporphyrin IX [math]\displaystyle{ \rightleftharpoons }[/math] beta-hematin
This heme detoxifying enzyme is found in Plasmodium parasites.
References
- ↑ "HDP-a novel heme detoxification protein from the malaria parasite". PLOS Pathogens 4 (4): e1000053. April 2008. doi:10.1371/journal.ppat.1000053. PMID 18437218.
External links
- Heme+ligase at the US National Library of Medicine Medical Subject Headings (MeSH)
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