Biology:Hepatitis B virus PRE 1151-1410
From HandWiki
| Hepatitis B virus PRE 1151-1410 | |
|---|---|
 Predicted secondary structure and sequence conservation of Hepatitis B virus PRE 1151-1410 | |
| Identifiers | |
| Rfam | RF02816 |
| Other data | |
| Domain(s) | Viruses |
| GO | 0051168,0043484 |
| SO | 0005836 |
| PDB structures | PDBe |
Hepatitis B virus PRE 1151-1410 (HBV post-transcriptional regulatory element, nucleotides 1151-1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the HBV RNA export element.[1][2][3] However, the function is controversial and new regulatory elements have been predicted within PRE.[4] PRE 1151-1410 enhances nuclear export of intronless transcripts and represses the splicing mechanism to a comparable degree to that of the full-length PRE. Hence it was proposed to be the core HBV PRE element.[4] PRE1151-1410 contains 3 known regulatory elements: PRE SL-alpha (nucleotides 1292-1321),[5] human La protein binding site (nucleotide 1275-1291),[6] SRE-1 (nucleotides 1252-1348).[7]
See also
- HBV PRE SL alpha
- HBV PRE SL beta
- HBV RNA encapsidation signal epsilon
References
- ↑ Panjaworayan, Nattanan; Roessner, Stephan K.; Firth, Andrew E.; Brown, Chris M. (2007-12-17). "HBVRegDB: annotation, comparison, detection and visualization of regulatory elements in hepatitis B virus sequences". Virology Journal 4: 136. doi:10.1186/1743-422X-4-136. ISSN 1743-422X. PMID 18086305.
- ↑ Huang, J.; Liang, T. J. (December 1993). "A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products". Molecular and Cellular Biology 13 (12): 7476–7486. ISSN 0270-7306. PMID 8246965.
- ↑ Huang, Z. M.; Yen, T. S. (May 1994). "Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm". Journal of Virology 68 (5): 3193–3199. ISSN 0022-538X. PMID 8151782.
- ↑ 4.0 4.1 Visootsat, Akasit; Payungporn, Sunchai; T-Thienprasert, Nattanan P. (December 2015). "A conserved RNA structural element within the hepatitis B virus post-transcriptional regulatory element enhance nuclear export of intronless transcripts and repress the splicing mechanism". Molecular Biology Reports 42 (12): 1603–1614. doi:10.1007/s11033-015-3928-0. ISSN 1573-4978. PMID 26514143.
- ↑ Panjaworayan, Nattanan; Payungporn, Sunchai; Poovorawan, Yong; Brown, Chris M. (2010-09-08). "Identification of an effective siRNA target site and functional regulatory elements, within the hepatitis B virus posttranscriptional regulatory element". Virology Journal 7: 216. doi:10.1186/1743-422X-7-216. ISSN 1743-422X. PMID 20822550.
- ↑ Ehlers, Imke; Horke, Sven; Reumann, Kerstin; Rang, Andreas; Grosse, Frank; Will, Hans; Heise, Tilman (2004-10-15). "Functional characterization of the interaction between human La and hepatitis B virus RNA". The Journal of Biological Chemistry 279 (42): 43437–43447. doi:10.1074/jbc.M402227200. ISSN 0021-9258. PMID 15302879.
- ↑ Heise, Tilman; Sommer, Gunhild; Reumann, Kerstin; Meyer, Imke; Will, Hans; Schaal, Heiner (2006). "The hepatitis B virus PRE contains a splicing regulatory element". Nucleic Acids Research 34 (1): 353–363. doi:10.1093/nar/gkj440. ISSN 1362-4962. PMID 16410615.
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