Biology:Hofbauer cell
Hofbauer cells are oval eosinophilic histiocytes[1] with granules and vacuoles found in the placenta, which are of mesenchymal origin, in mesoderm of the chorionic villus, particularly numerous in early pregnancy.
Etymology
They are named after J. Isfred Isidore Hofbauer (1871[2]-1961),[1] a German-American gynecologist who described the cell type in his book Grundzüge einer Biologie der menschlichen Plazenta, mit besonderer Berücksichtigung der Fragen der fötalen Ernährung (Biology of the Human Placenta with a special emphasis on the question of fetal nourishment).
Function
They are believed to be a type of macrophage[3][4] and are most likely involved in preventing the transmission of pathogens from the mother to the fetus (vertical transmission). Although there are many studies concerning placental vasculogenesis and angiogenesis, there has been a lack of evidence on the possible roles of Hofbauer cells in these processes.[5] According to a systems level single-cell transcriptomics based study of human placental cell-cell communication, Hofbauer cells produce HBEGF, an EGFR ligand, which drives differentiation of villous cytotrophoblasts (VCT) towards syncytiotrophoblasts (SCT).[6]
Histology
Under histology sections, Hofbauer cells have appeared with discernible amount of cytoplasm.
See also
References
- ↑ 1.0 1.1 Venes, Donald (2006). Taber's cyclopedic medical dictionary (Ed. 20, illustrated in full color. ed.). Philadelphia [Pa.]: Davis Co.. ISBN 0-8036-1208-7. https://archive.org/details/taberscyclopedic19vene.
- ↑ "Dr. Isfred Hofbauer, a Gynecologist, 89" (in en-US). The New York Times. 1961-03-15. ISSN 0362-4331. https://www.nytimes.com/1961/03/15/archives/dr-isfred-hofbauer-a-gynecologist-89.html.
- ↑ Wood, GW. (1980). "Mononuclear phagocytes in the human placenta.". Placenta 1 (2): 113–23. doi:10.1016/s0143-4004(80)80019-1. PMID 7003580.
- ↑ Zaccheo, D.; Pistoia, V.; Castellucci, M.; Martinoli, C. (1989). "Isolation and characterization of Hofbauer cells from human placental villi.". Arch Gynecol Obstet 246 (4): 189–200. doi:10.1007/bf00934518. PMID 2482706.
- ↑ Seval, Y.; Korgun, ET.; Demir, R. (2007). "Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis.". Placenta 28 (8–9): 841–5. doi:10.1016/j.placenta.2007.01.010. PMID 17350092.
- ↑ Vento-Tormo, Roser; Efremova, Mirjana; Botting, Rachel A.; Turco, Margherita Y.; Vento-Tormo, Miquel; Meyer, Kerstin B.; Park, Jong-Eun; Stephenson, Emily et al. (2018). "Single-cell reconstruction of the early maternal–fetal interface in humans". Nature 563 (7731): 347–353. doi:10.1038/s41586-018-0698-6. ISSN 0028-0836. PMID 30429548. PMC 7612850. Bibcode: 2018Natur.563..347V. https://eprint.ncl.ac.uk/fulltext.aspx?url=253209/5307C9D4-195F-4436-8401-914EEFAD7198.pdf&pub_id=253209.
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