Biology:IER3

Generic protein structure example

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.

Further reading

• Wu MX (2003). "Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis.". Apoptosis 8 (1): 11–8. doi:10.1023/A:1021688600370. PMID 12510147. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line.". Cancer Res. 56 (11): 2641–8. 1996. PMID 8653710. 
• "Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine.". Biochem. Biophys. Res. Commun. 235 (1): 4–9. 1997. doi:10.1006/bbrc.1997.6715. PMID 9196025. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene.". Biochem. Biophys. Res. Commun. 245 (3): 651–7. 1998. doi:10.1006/bbrc.1998.8500. PMID 9588170. 
• "The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB.". FEBS Lett. 436 (2): 139–43. 1998. doi:10.1016/S0014-5793(98)01109-0. PMID 9781666. 
• "Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3.". Biochem. Biophys. Res. Commun. 251 (3): 868–73. 1998. doi:10.1006/bbrc.1998.9556. PMID 9791001. 
• "A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes.". Biochem. Biophys. Res. Commun. 253 (2): 336–41. 1999. doi:10.1006/bbrc.1998.9692. PMID 9878538. 
• "The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo.". Biochem. Biophys. Res. Commun. 262 (1): 139–45. 1999. doi:10.1006/bbrc.1999.1131. PMID 10448082. 
• "Expression of an immediate early gene, IEX-1, in human tissues.". Histochem. Cell Biol. 115 (6): 489–97. 2001. doi:10.1007/s004180100284. PMID 11455449. 
• "Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 878–83. 2002. doi:10.1073/pnas.022326699. PMID 11782530. 
• "Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1.". J. Biol. Chem. 277 (17): 14612–21. 2002. doi:10.1074/jbc.M109414200. PMID 11844788. 
• "Identification of mechanically induced genes in human monocytic cells by DNA microarrays.". J. Hypertens. 20 (4): 685–91. 2002. doi:10.1097/00004872-200204000-00026. PMID 11910304. 
• "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression.". Oncogene 21 (23): 3706–14. 2002. doi:10.1038/sj.onc.1205450. PMID 12032839. 
• "IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.". EMBO J. 21 (19): 5151–63. 2002. doi:10.1093/emboj/cdf488. PMID 12356731. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.