Biology:INSL4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Early placenta insulin-like peptide is a protein that in humans is encoded by the INSL4 gene.[1][2][3]
INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast.[3]
References
- ↑ "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta". Genomics 29 (2): 465–70. Aug 1996. doi:10.1006/geno.1995.9980. PMID 8666396.
- ↑ "The INSL4 gene maps close to WI-5527 at 9p24.1→p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome". Cytogenet Cell Genet 81 (3–4): 275–7. Oct 1998. doi:10.1159/000015045. PMID 9730618.
- ↑ 3.0 3.1 "Entrez Gene: INSL4 insulin-like 4 (placenta)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3641.
Further reading
- "Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family". J. Biol. Chem. 271 (34): 20238–41. 1996. doi:10.1074/jbc.271.34.20238. PMID 8702754.
- "Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta". J. Clin. Endocrinol. Metab. 82 (9): 3169–72. 1997. doi:10.1210/jcem.82.9.4359. PMID 9284764.
- "Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues". Mol. Reprod. Dev. 51 (2): 123–9. 1999. doi:10.1002/(SICI)1098-2795(199810)51:2<123::AID-MRD1>3.0.CO;2-S. PMID 9740319.
- "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. 2002. doi:10.1210/jc.2002-021093. PMID 12414911.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element". Biol. Reprod. 68 (4): 1422–9. 2004. doi:10.1095/biolreprod.102.010322. PMID 12606452.
- "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth". Biol. Reprod. 73 (4): 695–702. 2006. doi:10.1095/biolreprod.105.039859. PMID 15958731.
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