Biology:INSM1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.[1][2][3]
Function
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[3] [4]
Interactions
INSM1 has been shown to interact with SORBS1.[5]
References
- ↑ "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1". The Journal of Biological Chemistry 269 (19): 14170–4. May 1994. doi:10.1016/S0021-9258(17)36770-4. PMID 8188699.
- ↑ "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases". The Biochemical Journal 397 (1): 169–77. July 2006. doi:10.1042/BJ20051669. PMID 16569215.
- ↑ 3.0 3.1 "Entrez Gene: INSM1 insulinoma-associated 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3642.
- ↑ "Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections". Modern Pathology 32 (1): 100–109. August 2018. doi:10.1038/s41379-018-0122-7. PMID 30154579.
- ↑ "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics 80 (1): 54–61. July 2002. doi:10.1006/geno.2002.6800. PMID 12079283.
Further reading
- "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs". The Journal of Biological Chemistry 267 (21): 15252–7. July 1992. doi:10.1016/S0021-9258(18)42173-4. PMID 1634555.
- "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1". Biochemical and Biophysical Research Communications 236 (3): 776–81. July 1997. doi:10.1006/bbrc.1997.7054. PMID 9245732. https://zenodo.org/record/1229486.
- "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence". Nucleic Acids Research 30 (4): 1038–45. February 2002. doi:10.1093/nar/30.4.1038. PMID 11842116.
- "Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells". Pancreas 24 (2): 139–45. March 2002. doi:10.1097/00006676-200203000-00004. PMID 11854618.
- "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics 80 (1): 54–61. July 2002. doi:10.1006/geno.2002.6800. PMID 12079283.
- "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system". The Journal of Biological Chemistry 278 (40): 38991–7. October 2003. doi:10.1074/jbc.M306795200. PMID 12890672.
- "Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest". The Journal of Biological Chemistry 284 (9): 5574–81. February 2009. doi:10.1074/jbc.M808843200. PMID 19124461.
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