Biology:Inverse vaccine
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An inverse vaccine, or reverse vaccine, is a hypothetical approach to the use of vaccines that trains the immune system to not respond to certain substances. Under laboratory conditions, an inverse vaccine has been shown to combat autoimmune diseases.[1] An autoimmune disease attacks the body's own cells and substances, an inverse vaccine must counteract this. The current method of combating the effects of an autoimmune disease is to suppress the entire immune system, which means that infections cannot be fought.
Approaches
As of 2010, human trials were underway using naked DNA that encoded specific antigens of interests, particularly for multiple sclerosis using BHT-3009, and type 1 diabetes mellitus.[2]
Possible applications
Possible applications of inverse vaccines include:[3]
- Multiple Sclerosis (MS)[4]
- Type 1 diabetes
- Psoriasis
- Coeliac disease
- Allergic asthma
- Food allergies[5]
- Chronic inflammatory diseases, such as Crohn's disease
- Preventing an immune response after an organ transplant
- Rheumatoid arthritis[6]
As of 2024, a study is underway into the safety of an inverse vaccine against multiple sclerosis, with a small group of patients and volunteers; for an inverse vaccine against celiac disease, a study into safety and efficacy was conducted in a limited group of subjects with good results, but the company that conducted the study went bankrupt in 2025.[3][7][8][9]
See also
- Allergen immunotherapy, an analogous technique for the treatment of allergy
References
- ↑ Sarah C.P. Williams (2023-09-11). ""Inverse vaccine" shows potential to treat multiple sclerosis and other autoimmune diseases". https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases. "A new type of vaccine developed by researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes — all without shutting down the rest of the immune system."
- ↑ Steinman, L. (May 2010). "Inverse vaccination, the opposite of Jenner's concept, for therapy of autoimmunity". Journal of Internal Medicine 267 (5): 441–451. doi:10.1111/j.1365-2796.2010.02224.x. PMID 20433574.
- ↑ 3.0 3.1 "Autoimmune Diseases and the Promise of Inverse Vaccines". 2023-10-02. https://www.civilsdaily.com/news/autoimmune-diseases-and-inverse-vaccines/. "In the quest to combat autoimmune diseases, scientists are exploring a groundbreaking approach: inverse vaccines. While still in the developmental stage and yet to be tested on humans, this novel concept holds the potential to revolutionize the treatment of autoimmune diseases."
- ↑ Maia, Margarida (2024-04-05). "Nykode's 'inverse vaccine' found to prevent MS in mouse model". Bionews, Inc.. https://multiplesclerosisnewstoday.com/news-posts/2024/04/05/nykode-inverse-vaccine-found-prevent-ms-mouse-model/. "The vaccine, known as a Vaccibody, is designed to teach the immune system to recognize certain proteins as self without impacting other immune cell functions, as is often seen with current MS therapies."
- ↑ Dr. Jeffrey A. Hubbell; Dr. Cathryn R. Nagler (2023-07-10). "Inverse Food Allergy Vaccines Through Targeted Antigen Delivery — Food Allergy Fund". https://foodallergyfund.org/research-1/2021/2/15/inverse-food-allergy-vaccines-through-targeted-antigen-delivery. "Researchers know that something called “food antigens” create tolerance for specific food proteins. Now researchers want to create an inverse vaccine that puts those particular food antigens to work inside of food allergic individuals so they can tolerate their allergens."
- ↑ Thumsi, Abhirami; Martínez, Diego; Swaminathan, Srivatsan J.; Esrafili, Arezoo; Suresh, Abhirami P.; Jaggarapu, Madhan Mohan Chandrasekhar; Lintecum, Kelly; Halim, Michelle et al. (19 March 2024). "Inverse-Vaccines for Rheumatoid Arthritis Re-establish Metabolic and Immunological Homeostasis in Joint Tissues". Advanced Healthcare Materials. doi:10.1002/adhm.202303995.
- ↑ "A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in Celiac Disease (ACeD-it)". 2024-01-16. https://clinicaltrials.gov/study/NCT05574010?term=KAN-101. "This study is to evaluate the Pharmacodynamic (PD), safety, tolerability, Pharmacokinetic (PK), and plasma biomarker response of KAN-101 in participants with Celiac Disease (CeD)."
- ↑ "Anokion Announces Positive Symptom Data from its Phase 2 Trial Evaluating KAN-101 for the Treatment of Celiac Disease". 2025-01-08. https://www.biospace.com/press-releases/anokion-announces-positive-symptom-data-from-its-phase-2-trial-evaluating-kan-101-for-the-treatment-of-celiac-disease. "The data indicate KAN-101 reduces multiple gluten induced symptoms and celiac-specific composite measures in a Phase 2 trial"
- ↑ "Anokion SA en liquidation in Ecublens VD | Moneyhouse". 2025-07-29. https://www.moneyhouse.ch/en/company/anokion-sa-13371665431.
External links
- What is an inverse vaccine and how can it reverse autoimmune disorders? (Video)
- Inverse vaccination, the opposite of Jenner’s concept, for therapy of autoimmunity
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