Biology:JAML
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Short description: Protein
 Generic protein structure example |
JAML or Junctional Adhesion Molecule-Like, or AMICA1 is a JAM transmembrane protein family member.[1][2] It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling. A known ligand of JAML is Coxsackie virus and Adenovirus Receptor (CXADR in humans and CAR in mice) which has been shown to localize to the tight junctions of epithelial cells.
JAML-mediated activation of CAR is required for neutrophil extravasation[3] in addition to other leukocyte/epithelial cell interaction models.
Other members of the JAM family of transmembrane proteins include JAM1, JAM2 and JAM3.
References
- ↑ "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res 13 (10): 2265–70. Oct 2003. doi:10.1101/gr.1293003. PMID 12975309.
- ↑ "Entrez Gene: AMICA1 adhesion molecule, interacts with CXADR antigen 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=120425.
- ↑ Zen, K.; Liu, Y; McCall, IC; Wu, T; Lee, W; Babbin, BA; Nusrat, A; Parkos, CA (2005). "Neutrophil Migration across Tight Junctions is Mediated by Adhesive Interactions between Epithelial Coxsackie and Adenovirus Receptor and a Junctional Adhesion Molecule-like Protein on Neutrophils". Molecular Biology of the Cell 16 (6): 2694–703. doi:10.1091/mbc.E05-01-0036. PMID 15800062.
Further reading
- Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Zen K; Liu Y; McCall IC et al. (2005). "Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils". Mol. Biol. Cell 16 (6): 2694–703. doi:10.1091/mbc.E05-01-0036. PMID 15800062.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Moog-Lutz C; Cavé-Riant F; Guibal FC et al. (2004). "JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells". Blood 102 (9): 3371–8. doi:10.1182/blood-2002-11-3462. PMID 12869515.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Dias Neto E; Correa RG; Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
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