Biology:JAM2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.[1][2][3] JAM2 has also been designated as CD322 (cluster of differentiation 322).

Function

Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.[3]

It is purported to promote lymphocyte transendothelial migration.[4] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PARD3 (PAR-3), together with JAM3.[5]

Interactions

JAM2 has been shown to interact with PARD3.[5]

It also interacts with the integrin dimer VLA-4 (also called α4β1).[6]

References

  1. "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells". J Biol Chem 275 (25): 19139–45. Aug 2000. doi:10.1074/jbc.M003189200. PMID 10779521. 
  2. "A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions". J Biol Chem 275 (44): 34750–6. Nov 2000. doi:10.1074/jbc.M002718200. PMID 10945976. 
  3. 3.0 3.1 "Entrez Gene: JAM2 junctional adhesion molecule 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58494. 
  4. "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration". Blood 100 (7): 2479–86. October 2002. doi:10.1182/blood-2001-11-0098. PMID 12239159. 
  5. 5.0 5.1 "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. October 2003. doi:10.1242/jcs.00704. PMID 12953056. 
  6. "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. August 2002. doi:10.1074/jbc.C200331200. PMID 12070135. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.