Biology:KDM3A
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene.[1]
Function
This gene encodes a zinc finger protein that contains a jumonji C (JmjC) domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. KDM3A catalyzes the demethylation of H3K9me1 and H3K9me2 residues. Its function is dependent on the presence of cofactors Fe(II) and α-Ketoglutarate.[2]
References
- ↑ "Entrez Gene: Lysine demethylase 3A". https://www.ncbi.nlm.nih.gov/gene/55818.
- ↑ "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor". Cell 125 (3): 483–495. May 2006. doi:10.1016/j.cell.2006.03.027. PMID 16603237.
Further reading
- "Hypoxia upregulates the histone demethylase JMJD1A via HIF-1". Biochemical and Biophysical Research Communications 372 (4): 892–897. August 2008. doi:10.1016/j.bbrc.2008.05.150. PMID 18538129.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
