Biology:KLK10
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.[1][2][3][4][5]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.[5]
References
- ↑ "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression". Cancer Res 56 (14): 3371–9. Sep 1996. PMID 8764136.
- ↑ "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping". Cytogenet Cell Genet 79 (1–2): 147–8. Apr 1998. doi:10.1159/000134705. PMID 9533035. https://zenodo.org/record/1235424.
- ↑ "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. Jun 2006. doi:10.1515/BC.2006.082. PMID 16800724. https://epub.ub.uni-muenchen.de/17786/.
- ↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
- ↑ 5.0 5.1 "Entrez Gene: KLK10 kallikrein-related peptidase 10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5655.
Further reading
- "The new human kallikrein gene family: implications in carcinogenesis.". Trends Endocrinol. Metab. 11 (2): 54–60. 2001. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891.
- "Human kallikrein 10, a predictive marker for breast cancer.". Biol. Chem. 387 (6): 715–21. 2006. doi:10.1515/BC.2006.090. PMID 16800732.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Structural characterization and mapping of the normal epithelial cell-specific 1 gene.". Biochem. Biophys. Res. Commun. 247 (3): 580–6. 1998. doi:10.1006/bbrc.1998.8793. PMID 9647736.
- "The role for NES1 serine protease as a novel tumor suppressor.". Cancer Res. 58 (21): 4782–6. 1998. PMID 9809976.
- "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.". J. Biol. Chem. 275 (48): 37397–406. 2001. doi:10.1074/jbc.M004525200. PMID 10969073.
- "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.". Gene 257 (1): 119–30. 2001. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
- "Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer.". Clin. Cancer Res. 7 (11): 3393–8. 2002. PMID 11705853.
- "Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers.". Prostate 51 (1): 35–41. 2002. doi:10.1002/pros.10076. PMID 11920956.
- "Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance.". Br. J. Cancer 86 (11): 1790–6. 2002. doi:10.1038/sj.bjc.6600323. PMID 12087468.
- "Human kallikrein 10 expression in normal tissues by immunohistochemistry.". J. Histochem. Cytochem. 50 (9): 1247–61. 2002. doi:10.1177/002215540205000912. PMID 12185203.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues.". Prostate Cancer Prostatic Dis. 6 (3): 223–7. 2004. doi:10.1038/sj.pcan.4500674. PMID 12970725.
- "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk.". Int. J. Cancer 108 (4): 588–91. 2004. doi:10.1002/ijc.11607. PMID 14696124.
- "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.". Clin. Biochem. 37 (3): 230–7. 2004. doi:10.1016/j.clinbiochem.2003.11.012. PMID 14972646.
- "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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