Biology:KLK12

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.[1][2][3]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[3]

References

  1. "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. Jun 2006. doi:10.1515/BC.2006.082. PMID 16800724. http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-17786-5. 
  2. Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  3. 3.0 3.1 "Entrez Gene: KLK12 kallikrein-related peptidase 12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=43849. 

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: S01.020