Biology:KLRA1
From HandWiki
| killer cell lectin-like receptor, subfamily A, member 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Klra2 | ||||||
| Alt. symbols | Ly49b; Klra30 | ||||||
| Entrez | 16633 | ||||||
| RefSeq (mRNA) | NM_008462.5 | ||||||
| RefSeq (Prot) | NP_032488.4 | ||||||
| UniProt | Q60660 | ||||||
| Other data | |||||||
| Chromosome | 6: 131.22 - 131.25 Mb | ||||||
| |||||||
| Killer cell lectin-like receptor subfamily A pseudogene 1 | |
|---|---|
| Identifiers | |
| Symbol | KLRAP1 |
| Alt. symbols | KLRA1; Ly49; LY49L; Ly-49L |
| NCBI gene | 10748 |
| HGNC | 6372 |
| OMIM | 604274 |
| RefSeq | NM_006611 |
| UniProt | O75889 |
| Other data | |
| Locus | Chr. 12 p12-p13 |
Killer cell lectin-like receptor subfamily A (KLRA, alternative nomenclature Ly49) is a gene cluster coding proteins from family Ly49, which are membrane receptors expressed mainly on the surface of NK cells and other cells of immune system in some mammals including rodents and cattle but not humans.[1][2] Mouse Klra gene cluster is located on chromosome 6 and comprises 20-30 genes and pseudogenes, e.g. Klra1 (Ly49A).[2][3] Klra gene family is highly polymorphic and polygenic and various mouse strains encode different number of Klra genes.[2][4]
The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).[5][6]
References
- ↑ "Ly49 receptors: innate and adaptive immune paradigms". Frontiers in Immunology 5: 145. 2014-04-02. doi:10.3389/fimmu.2014.00145. PMID 24765094.
- ↑ 2.0 2.1 2.2 "The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection". Frontiers in Immunology 4: 90. 2013. doi:10.3389/fimmu.2013.00090. PMID 23596445.
- ↑ "Klra MGI Mouse Complex/Cluster/Region Detail - MGI:96876 - killer cell lectin-like receptor, subfamily A". http://www.informatics.jax.org/marker/MGI:96876.
- ↑ "Ly49 receptors: evolution, genetic diversity, and impact on immunity". Immunological Reviews 267 (1): 137–47. September 2015. doi:10.1111/imr.12318. PMID 26284475.
- ↑ "The human Ly-49L gene". Immunogenetics 49 (7–8): 731–4. July 1999. doi:10.1007/s002510050675. PMID 10369937.
- ↑ "Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals". Proceedings of the National Academy of Sciences of the United States of America 103 (9): 3192–7. February 2006. doi:10.1073/pnas.0511280103. PMID 16492762.
External links
- Ly-49+antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
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