Biology:KYAT1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Kynurenine—oxoglutarate transaminase 1 is an enzyme that in humans is encoded by the CCBL1 gene. It is one of the Kynurenine—oxoglutarate transaminases.

This gene encodes a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity.

External links

• Human CCBL1 genome location and CCBL1 gene details page in the UCSC Genome Browser.

Further reading

• Cooper AJ (2004). "The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants". Neurochem. Int. 44 (8): 557–77. doi:10.1016/j.neuint.2003.12.002. PMID 15016471. 
• "Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity". Drug Metab. Dispos. 18 (1): 50–4. 1990. PMID 2139845. 
• "Isolation from rat kidney of a cytosolic high molecular weight cysteine-S-conjugate beta-lyase with activity toward leukotriene E4". J. Biol. Chem. 270 (1): 180–8. 1995. doi:10.1074/jbc.270.1.180. PMID 7814371. 
• Goldfarb P; Perry S; Harries H et al. (1996). "Molecular cloning and expression of cDNAs for rat and human kidney cysteine conjugate beta-lyase". Biochem. Soc. Trans. 24 (2): 330S. doi:10.1042/bst024330s. PMID 8736988. 
• "Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product compound A in human, nonhuman primate, and rat kidney cytosol and mitochondria". Anesthesiology 85 (6): 1454–61. 1997. doi:10.1097/00000542-199612000-00028. PMID 8968194. 
• "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Hum. Mol. Genet. 8 (7): 1313–20. 1999. doi:10.1093/hmg/8.7.1313. PMID 10369878. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Humphray SJ; Oliver K; Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
• Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
• Kapoor R; Lim KS; Cheng A et al. (2006). "Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1)". Brain Res. 1106 (1): 205–10. doi:10.1016/j.brainres.2006.05.082. PMID 16828464.