Biology:Keratin 15
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Keratin 15 is a protein that in humans is encoded by the KRT15 gene.[1][2] It has also been referred to as cytokeratin 15, K1CO and KRTB.
Keratin 15 is a type I cytokeratin. It is well-expressed in the basal layer of complex epithelia. However, acral keratinocytes express little to no keratin 15.[3]
References
- ↑ "Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization". Cytogenetics and Cell Genetics 54 (3–4): 148–150. 1990. doi:10.1159/000132979. PMID 1702379.
- ↑ "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology 174 (2): 169–174. July 2006. doi:10.1083/jcb.200603161. PMID 16831889.
- ↑ "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight 7 (16): e159762. August 2022. doi:10.1172/jci.insight.159762. PMID 35900871.
Further reading
- "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription". Molecular and Cellular Biology 24 (8): 3168–3179. April 2004. doi:10.1128/MCB.24.8.3168-3179.2004. PMID 15060141.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin". Aging Cell 8 (6): 738–751. December 2009. doi:10.1111/j.1474-9726.2009.00526.x. PMID 20050020.
- "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes". The Journal of Investigative Dermatology 112 (3): 362–369. March 1999. doi:10.1046/j.1523-1747.1999.00535.x. PMID 10084315.
- "Linkage of human keratin genes". Cytogenetics and Cell Genetics 42 (1–2): 65–71. 1986. doi:10.1159/000132253. PMID 2424675.
- "Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene". Proceedings of the National Academy of Sciences of the United States of America 82 (6): 1609–1613. March 1985. doi:10.1073/pnas.82.6.1609. PMID 2580298. Bibcode: 1985PNAS...82.1609M.
- "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene". European Journal of Cell Biology 47 (2): 300–319. December 1988. PMID 2468493.
- "Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma". The Journal of Dermatology 35 (8): 499–502. August 2008. doi:10.1111/j.1346-8138.2008.00510.x. PMID 18789069.
- "Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes". Cytogenetics and Cell Genetics 48 (3): 148–151. 1988. doi:10.1159/000132612. PMID 2466616.
- "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15". The Journal of Cell Biology 106 (4): 1249–1261. April 1988. doi:10.1083/jcb.106.4.1249. PMID 2452170.
- "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell 31 (1): 243–252. November 1982. doi:10.1016/0092-8674(82)90424-X. PMID 6186381. https://zenodo.org/record/890743.
- "Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease". Molecular Oncology 1 (3): 321–349. December 2007. doi:10.1016/j.molonc.2007.09.004. PMID 19383306.
- "Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo". Experimental Cell Research 254 (1): 80–90. January 2000. doi:10.1006/excr.1999.4726. PMID 10623468.
- "Genomic organization and amplification of the human keratin 15 and keratin 19 genes". Biochemical and Biophysical Research Communications 267 (1): 462–465. January 2000. doi:10.1006/bbrc.1999.1966. PMID 10623642.
- "Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus". Autoimmunity Reviews 8 (6): 474–477. May 2009. doi:10.1016/j.autrev.2008.12.015. PMID 19162247.
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