Biology:Klerokinesis
Klerokinesis (from the Greek root for allotted inheritance) is a phrase of mitosis . It is thought to serve as a natural back-up mechanism during faulty cell division (cytokinesis), thus preventing some cells from forming into cancer cells.[1] It is considered to be a recovery mechanism.[2]
Discovery
The new cellular process was identified when researchers at University of Wisconsin were blocking cells from undergoing cytokinesis — a process during cell division in which the cytoplasm of a single eukaryotic cell is divided to form two daughter cells.[2] The group generated a population of human retinal pigment epithelial (RPE) cells that would undergo karyokinesis but miss the cytokinesis stage.[2] Using live cell imaging,[3] klerokinesis was found while studying human RPE cells to establish the hypothesis of German biologist Theodor Boveri, that the presence of an abnormal number of sets of chromosomes in a cell (polyploidy) would lead to out-of-control cell division, causing cancer.[4] However, contrary to Boveri's hypothesis, researchers found that abnormal cell division rarely has long-term negative effects in human cells, rather, some cell divisions occurred later than the end of mitosis in such a way that the normal chromosome complement was restored.[5]
Similar divisions like klerokinesis have been observed in slime molds. It is thought that klerokinesis is a primitive mechanism of cell division that appears to be preserved in humans.[4] Researchers saw that this mechanism was happening about 90% of the time and that the cells were getting abnormal chromosome sets about 10% of the time.[2]
Klerokinesis was presented by a team from the UW Carbone Cancer Center[4] in 2012, at the annual meeting of the American Society for Cell Biology in San Francisco .[1]
See also
- Polyploid
- Cell division
- Cytokinesis
References
- ↑ 1.0 1.1 "New form of cell division found". http://news.wisc.edu/new-form-of-cell-division-found/. Retrieved 20 August 2016.
- ↑ 2.0 2.1 2.2 2.3 "New Cell Division". http://www.biotechniques.com/news/New-Cell-Division/biotechniques-338372.html#.V8Hwh_mGMhk. Retrieved 27 August 2016.
- ↑ "Newly discovered form of cell division may help ward off cancer". http://blogs.nature.com/spoonful/2012/12/video-newly-discovered-form-of-cell-division-may-help-ward-off-cancer.html#wpn-more-4171. Retrieved 20 August 2016.
- ↑ 4.0 4.1 4.2 "Cell Division May Prevent Cancer". http://www.natureworldnews.com/articles/408/20121218/cell-division-prevent-cancer-discovered.htm. Retrieved 20 August 2016.
- ↑ "New form of cell division found: Natural back-up mechanism during faulty cell division". https://www.sciencedaily.com/releases/2012/12/121217140328.htm. Retrieved 20 August 2016.
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