Biology:LILRA4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Leukocyte immunoglobulin-like receptor subfamily A member 4 is a protein that in humans is encoded by the LILRA4 gene.[1][2]
This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.[2]
References
- ↑ "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics 51 (8–9): 703–13. Sep 2000. doi:10.1007/s002510000187. PMID 10941842.
- ↑ 2.0 2.1 "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23547.
Further reading
- "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production". Int. Immunol. 20 (1): 155–64. 2008. doi:10.1093/intimm/dxm127. PMID 18048391.
- "Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis". Blood 111 (3): 1625–33. 2008. doi:10.1182/blood-2007-08-110130. PMID 18006695.
- "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. 2006. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
- "Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production". J. Exp. Med. 203 (6): 1399–405. 2006. doi:10.1084/jem.20052454. PMID 16735691.
- "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation". Gene 331: 159–64. 2004. doi:10.1016/j.gene.2004.02.018. PMID 15094202.
- "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. 2003. doi:10.1073/pnas.0337567100. PMID 12529506. Bibcode: 2003PNAS..100.1174T.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood 100 (9): 3295–303. 2002. doi:10.1182/blood-2002-02-0638. PMID 12384430.
- "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics 53 (4): 270–8. 2001. doi:10.1007/s002510100332. PMID 11491530.
 |
