Biology:LMO4
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LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.[1]
LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.[1]
Interactions
LMO4 has been shown to interact with LDB1,[2][3] RBBP8[2][4] and BRCA1.[2][4]
References
- ↑ 1.0 1.1 "Entrez Gene: LMO4 LIM domain only 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8543.
- ↑ 2.0 2.1 2.2 Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer 107 (1): 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972.
- ↑ Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMID 12727888.
- ↑ 4.0 4.1 Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. ISSN 0021-9258. PMID 11751867.
Further reading
- "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. 1998. doi:10.1073/pnas.95.19.11257. PMID 9736723. Bibcode: 1998PNAS...9511257K.
- "Molecular cloning of LMO41, a new human LIM domain gene.". Biochim. Biophys. Acta 1445 (1): 148–53. 1999. doi:10.1016/s0167-4781(99)00037-8. PMID 10209267.
- "Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.". Mamm. Genome 10 (11): 1089–94. 2000. doi:10.1007/s003359901167. PMID 10556429.
- "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.". J. Biol. Chem. 277 (10): 7849–56. 2002. doi:10.1074/jbc.M110603200. PMID 11751867.
- "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex.". J. Biomol. NMR 23 (2): 165–6. 2003. doi:10.1023/A:1016363414644. PMID 12153047.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells.". Brain Res. Mol. Brain Res. 115 (2): 93–103. 2003. doi:10.1016/S0169-328X(03)00119-0. PMID 12877980.
- "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1.". Biochem. Biophys. Res. Commun. 307 (4): 891–9. 2003. doi:10.1016/S0006-291X(03)01298-1. PMID 12878195.
- "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas.". Int. J. Cancer 107 (1): 155–8. 2003. doi:10.1002/ijc.11343. PMID 12925972.
- "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.". J. Biol. Chem. 280 (13): 12747–57. 2005. doi:10.1074/jbc.M500175200. PMID 15677447.
- "Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.". Science 308 (5729): 1794–8. 2005. doi:10.1126/science.1110324. PMID 15894532. Bibcode: 2005Sci...308.1794S.
- "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer.". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7659–64. 2005. doi:10.1073/pnas.0502990102. PMID 15897450. Bibcode: 2005PNAS..102.7659S.
- "Stabilization of a binary protein complex by intein-mediated cyclization.". Protein Sci. 15 (11): 2612–8. 2007. doi:10.1110/ps.062377006. PMID 17001033.
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