Biology:Lactoferricin
| Lactoferricin | |
|---|---|
| Identifiers | |
| Symbol | N/A |
| OPM superfamily | 203 |
| OPM protein | 1lfc |
Lactoferricin is an amphipathic, cationic peptide with anti-microbial[1] and anti-cancer[2] properties. It can be generated by the pepsin-mediated digestion of lactoferrin.
Lactoferricin is the most studied AMP derived from milk protein. The complete sequence of lactoferricin corresponds to lactoferrin fragment 17-41 (FKCRRWQWRM KKLGAPSITCVRRAF; LFB0084 ) and sequences from within this fragment are also antimicrobial. The MilkAMP database contains a total of 111 peptides (natural, synthetic and modified) comprising or derived from the complete lactoferricin.[1] In humans, lactoferricin corresponds to lactoferrin fragment 1-47 but consists of two subunits, namely fragments 1-11 and 12-47 (LFH0009 ), connected by a disulfide bridge.[3]
Human Lactoferricin and Bovine Lactoferricin are two greatly studied forms of Lactoferricin. These two forms have great sequence differences. Bovine Lactoferricin contains 25 residues, while Human Lactoferricin contains 49 residues.[4] Also, when placed in solution Bovine Lactoferricin forms a β-pleated sheet, while Human Lactoferricin forms a coiled structure.[5]
References
- ↑ 1.0 1.1 "Lactoferricin derived from milk protein lactoferrin". Current Pharmaceutical Design 9 (16): 1277–1287. 2003. doi:10.1007/s13594-013-0153-2. PMID 12769736. https://hal.archives-ouvertes.fr/hal-01234856/file/13594_2013_Article_153.pdf.
- ↑ "Evidence for a direct antitumor mechanism of action of bovine lactoferricin". Anticancer Research 22 (5): 2703–2710. 2002. PMID 12529985.
- ↑ "Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine". Molecules 21 (6): 752. June 2016. doi:10.3390/molecules21060752. PMID 27294909.
- ↑ "Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties". Cellular and Molecular Life Sciences 62 (22): 2588–2598. November 2005. doi:10.1007/s00018-005-5373-z. PMID 16261252.
- ↑ "Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent". Antimicrobial Agents and Chemotherapy 49 (8): 3387–3395. August 2005. doi:10.1128/AAC.49.8.3387-3395.2005. PMID 16048952.
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